Citation: Yupeng Shi, Jingjing Liu, Yong Zhang, Jianfeng Bao, Jingliang Cheng, Changqing Yi. Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe³⁺ detection and bioimaging[J]. Chinese Chemical Letters, ;2021, 32(10): 3189-3194. doi: 10.1016/j.cclet.2021.03.022 shu

Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe³⁺ detection and bioimaging

Yupeng Shi ^a ,
Jingjing Liu ^a ,
Yong Zhang ^a ,
Jianfeng Bao ^a ,
Jingliang Cheng ^{a, *,} ,
Changqing Yi ^{b, *,}

a.
Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging (Henan Province), Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
b.
Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical Devices, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China

fccchengjl@zzu.edu.cn

yichq@mail.sysu.edu.cn

Received Date: 6 December 2020
Revised Date: 6 February 2021
Accepted Date: 8 March 2021
Available Online: 11 March 2021

Figures(6)

Carbon nanodots (CDs) based fluorescent nanoprobes have recently drawn much attention in chemo-/bio-sensing and bioimaging. However, it is still challenging to integrate the colorimetric and fluorometric dual readouts into a single CD. Herein, novel hybrid CDs (HCDs) are prepared by a simple microwave-assisted reaction of citric acid (CA), branched polyethyleneimine (BPEI) and potassium thiocyanate (KSCN). As-prepared HCDs show extraordinary properties, including excitation-dependent emission, satisfactory fluorescence quantum yield (46.8%), excellent biocompatibility and optical stability. Significantly, the fluorescence intensity at 450 nm exhibits linear correlation over the Fe³⁺ concentration from 1 μmol/L to 150 μmol/L with a detection limit (LOD) of 52 nmol/L. Meanwhile, the solution color changes from colorless to orange, and the absorbance at 460 nm increased linearly with Fe³⁺ concentration ranging from 0.02 mmol/L to 5 mmol/L (LOD: 3.4 μmol/L). All the evidence illustrates that the HCDs can be conditioned for specific Fe³⁺ sensing with colorimetric and fluorometric dual readouts, which has also been verified with paper-based microchips. The possible mechanism is attributed to the specific interactions between surface functional groups on the HCDs and Fe³⁺. Additionally, the HCDs are successfully applied in sensing Fe³⁺ in wastewater and living cells, demonstrating its potential applications in future environment monitoring and disease diagnosis.
- Paper-based chip,
- Carbon nanodots,
- Colorimetric,
- Fluorescence,
- Fe³⁺ions detection,
- Dual-functional
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Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe3+ detection and bioimaging

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通讯作者: 陈斌, bchen63@163.com

Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe³⁺ detection and bioimaging