Citation: Jie Ren, Yanzhen Huang, Chao Pi, Xiuling Cui, Yangjie Wu. Rhodium(III)-catalyzed [4 + 2] annulation of N-arylbenzamidines with 1, 4, 2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective CH bond activation[J]. Chinese Chemical Letters, ;2021, 32(8): 2592-2596. doi: 10.1016/j.cclet.2021.02.061 shu

Rhodium(III)-catalyzed [4 + 2] annulation of N-arylbenzamidines with 1, 4, 2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective CH bond activation

Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450052, China

cuixl@zzu.edu.cn

wyj@zzu.edu.cn

Received Date: 6 January 2021
Revised Date: 24 February 2021
Accepted Date: 25 February 2021
Available Online: 27 February 2021

Figures(6)

A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(III)-catalyzed [4 + 2] annulation of N-arylbenzamidines with 1, 4, 2-dioxazol-5-ones. This reaction features excellent regioselectivity, broad substrate scope and high step economy, which would provide the reference for the construction of the fused 4-aminoquinazolines with biologically and pharmacologically active compounds.
- [4 + 2] Annulation,
- N-Arylbenzamidine,
- 4-Aminoquinazoline,
- Excellent regioselectivity,
- High step economy
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