Citation: Qiao Song, Yan Liu, Linlin Cai, Xinyu Cao, Shan Qian, Zhouyu Wang. One-pot tandem route to fused indolizidines and quinolizidines: Application in the synthesis of alkaloids and bioactive compounds[J]. Chinese Chemical Letters, ;2021, 32(5): 1713-1716. doi: 10.1016/j.cclet.2021.01.018 shu

One-pot tandem route to fused indolizidines and quinolizidines: Application in the synthesis of alkaloids and bioactive compounds

Qiao Song ^a ,
Yan Liu ^b ,
Linlin Cai ^b ,
Xinyu Cao ^b ,
Shan Qian ^{a, *} ,
Zhouyu Wang ^{b, *}

a.
Department of Pharmaceutics Engineering, Xihua University, Chengdu 610039, China
b.
Department of Chemistry, Xihua University, Chengdu 610039, China

qians33@163.com

zhouyuwang@mail.xhu.edu.cn

Received Date: 3 December 2020
Revised Date: 4 January 2021
Accepted Date: 12 January 2021
Available Online: 15 January 2021

Figures(8)

Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds. A one-pot tandem route from amide to fused indolizidines and quinolizidines is disclosed. This method is conducted in mild conditions and shows well tolerance of functional groups. It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as (±)-crispine A, (±)-xylopinine, (±)-desbromoarborescidine A, (±)-harmicine and other bioactive substances.
- One-pot,
- Indolizidines,
- Quinolizidines,
- Scalable,
- Alkaloids
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