Citation: Xiao-Qiao Hong, Yuan-Yuan Xing, Zhong-Kun Wang, Qin-Chao Mao, Wen-Hua Chen. Curvature-regulated transmembrane anion transport by a trifluoromethylated bisbenzimidazole[J]. Chinese Chemical Letters, ;2021, 32(5): 1653-1656. doi: 10.1016/j.cclet.2021.01.005 shu

Curvature-regulated transmembrane anion transport by a trifluoromethylated bisbenzimidazole

a.
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
b.
School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China
c.
Guangdong Maoming Health Vocational College, Maoming 525000, China
d.
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China

Received Date: 25 November 2020
Revised Date: 18 December 2020
Accepted Date: 4 January 2021
Available Online: 9 January 2021

Figures(6)

In this paper, we demonstrate that modification of anion-transport active 1, 3-bis(benzimidazol-2-yl) benzene with strongly electron-withdrawing trifluoromethyl and nitro groups leads to a dramatic increase in the anionophoric activity, and the activity may be greatly regulated by the curvatures of the liposomes used.
- Anion transporter,
- Lysosomal curvature,
- Anionophoric activity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142