Citation: Tao Liu, Hui Zou, Jingqing Mu, Na Yu, Yang Xu, Guohua Liu, Xingjie Liang, Shutao Guo. Acid-sensitive PEGylated cabazitaxel prodrugs for antitumor therapy[J]. Chinese Chemical Letters, ;2021, 32(5): 1751-1754. doi: 10.1016/j.cclet.2020.12.008 shu

Acid-sensitive PEGylated cabazitaxel prodrugs for antitumor therapy

Tao Liu ^{a, 1} ,
Hui Zou ^{a, 1} ,
Jingqing Mu ^a ,
Na Yu ^a ,
Yang Xu ^a ,
Guohua Liu ^a ,
Xingjie Liang ^{b, c} ,
Shutao Guo ^{a, *,}

a.
Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
b.
Laboratory of Controllable Nanopharmaceuticals, CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China

stguo@nankai.edu.cn

Received Date: 21 September 2020
Revised Date: 2 December 2020
Accepted Date: 7 December 2020
Available Online: 11 December 2020

Figures(5)

Although the antitumor drug cabazitaxel shows great therapeutic potential, its high toxicity and poor water solubility limit its utility. However, the use of stimuli-responsive prodrugs is a promising strategy for overcoming these limitations. Herein, we report the synthesis of two highly water soluble, acid-sensitive PEGylated acyclic-ketal-linked cabazitaxel prodrugs (PKCs) with improved antitumor efficacy. In an acidic tumor microenvironment, the PKCs hydrolyzed rapidly to release the native drug, whereas they were stable in the normal physiological environment. Compared with cabazitaxel injection, the PKCs had much higher maximum tolerated doses; and in an MDA-MB-231 subcutaneous xenograft nude mouse model, the PKCs showed better antitumor efficacy and safety than cabazitaxel injection. The prodrug strategy reported herein could be useful for the development of other water soluble, acid-sensitive prodrugs with improved efficacy.
- Prodrugs,
- Acid-sensitive,
- Antitumor therapy,
- Cabazitaxel,
- PEGylation
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