Citation: Junkai Zhao, Xuan Chen, Kwun-Hei Ho, Chao Cai, Cheuk-Wing Li, Mo Yang, Changqing Yi. Nanotechnology for diagnosis and therapy of rheumatoid arthritis: Evolution towards theranostic approaches[J]. Chinese Chemical Letters, ;2021, 32(1): 66-86. doi: 10.1016/j.cclet.2020.11.048 shu

Nanotechnology for diagnosis and therapy of rheumatoid arthritis: Evolution towards theranostic approaches

Junkai Zhao ^{a, 1} ,
Xuan Chen ^{a, 1} ,
Kwun-Hei Ho ^b ,
Chao Cai ^a ,
Cheuk-Wing Li ^c ,
Mo Yang ^{b, *,} ,
Changqing Yi ^{a, *,}

a.
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
b.
Department of Biomedical Engineering, the Hong Kong Polytechnic University, Hong Kong, China
c.
School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, United Kingdom

mo.yang@polyu.edu.hk

yichq@mail.sysu.edu.cn

Received Date: 7 September 2020
Revised Date: 19 November 2020
Accepted Date: 20 November 2020
Available Online: 1 December 2020

Figures(11)

Rheumatoid arthritis (RA), as a chronic autoimmune disease, damages the bone and cartilage of patients, and even leads to disability. Therefore, the diagnosis and treatment of RA is particularly important. However, due to the complexity of RA, it is difficult to make effective early diagnosis of RA, which is detrimental to RA treatment. Besides, long-term intake of anti-RA drugs can also cause damage to patients' organs. The emergence of nanotechnology provides the new train of thoughts for the diagnosis and treatment of RA. And the combination of diagnosis and therapy is an ideal method to solve the problem of disease management of RA patients. In this review, we summarize the mechanism and microenvironment of RA, discuss the commonly used diagnostic techniques and therapeutic drugs for RA, and review their advantages and disadvantages. New nanotherapy strategies such as drug-carrying nanoparticles, PTT, PDT are listed, and their applications in RA treatment are also summarized. In addition, multimodal imaging, combined therapy and responsive diagnosis and treatment are also summarized as important contents. At last, we also review typical nanocarriers that can be used in the integration of diagnosis and therapy, and discussed their potential applications in RA theranostics.
- Rheumatoid arthritis,
- Diagnosis,
- Therapy,
- Theranostics,
- Nanomedicine
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