Citation: Jiang Hu, Xinwei Yuan, Fei Wang, Huile Gao, Xilin Liu, Wei Zhang. The progress and perspective of strategies to improve tumor penetration of nanomedicines[J]. Chinese Chemical Letters, ;2021, 32(4): 1341-1347. doi: 10.1016/j.cclet.2020.11.006 shu

The progress and perspective of strategies to improve tumor penetration of nanomedicines

Jiang Hu ^a ,
Xinwei Yuan ^a ,
Fei Wang ^a ,
Huile Gao ^{b, *,} ,
Xilin Liu ^{a, *,} ,
Wei Zhang ^{a, *,}

a.
Department of Orthopedics, Sichuan Provincial People's Hospital & Sichuan Academy of Medical Sciences & Affiliated Hospital of University of Electronic Science and Technology, Chengdu 610072, China
b.
Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu 610041, China

Received Date: 30 September 2020
Revised Date: 20 November 2020
Accepted Date: 20 November 2020
Available Online: 4 November 2020

Figures(4)

Tumor penetration is important for effectively tumor targeting drug delivery. Recently, many researches are published to overcome the barriers that restrict tumor penetration and improve drug delivery efficiency. In the mini review, we first analyzed the barriers influence the tumor penetration, including tumor microenvironment barriers, nanoparticle properties, and interaction barriers between tumor and nanoparticles. To overcome the barrier, several strategies are developed, including modulating tumor microenvironment, changing particle size, transcytosis enabled tumor penetration, cell penetrating peptide modification and overcoming binding site barrier, which could effectively improve tumor penetration, and finally enhance tumor treatment outcome.
- Tumor penetration,
- Tumor microenvironment,
- Size changeable,
- Cell penetrating peptide,
- Nanoparticles
1. [1]
  C. Li, J. Wang, Y. Wang, et al., Acta Pharm. Sin. B 9(2019) 1145-1162. doi: 10.1016/j.apsb.2019.08.003
2. [2]
  J. Cao, D. Huang, N.A. Peppas, Adv. Drug Deliv. Rev. 167(2020) 170-188. doi: 10.1016/j.addr.2020.06.030
3. [3]
  D. Bobo, K.J. Robinson, J. Islam, et al., Pharm. Res. 33(2016) 2373-2387. doi: 10.1007/s11095-016-1958-5
4. [4]
  M. Merino, S. Zalba, M.J. Garrido, J. Control. Release 275(2018) 162-176. doi: 10.1016/j.jconrel.2018.02.015
5. [5]
  U. Bulbake, S. Doppalapudi, N. Kommineni, et al., Pharmaceutics 9(2017) 12. doi: 10.3390/pharmaceutics9020012
6. [6]
  Q. Sun, Z. Zhou, N. Qiu, et al., Adv. Mater. 29(2017) 1606628. doi: 10.1002/adma.201606628
7. [7]
  M. De Palma, D. Biziato, T.V. Petrova, Nat. Rev. Cancer 17(2017) 457-474. doi: 10.1038/nrc.2017.51
8. [8]
  H. Gao, Curr. Drug Metab. 17(2016) 731-736. doi: 10.2174/1389200217666160630203600
9. [9]
  Y. Zhou, X. Chen, J. Cao, et al., J. Mater. Chem. B 8(2020) 6765-6781. doi: 10.1039/D0TB00649A
10. [10]
  S. Yang, H. Gao, Pharmacol. Res. 126(2017) 97-108. doi: 10.1016/j.phrs.2017.05.004
11. [11]
  P. Zheng, Y. Liu, J. Chen, et al., Chin. Chem. Lett. 31(2020) 1178-1182. doi: 10.1016/j.cclet.2019.12.001
12. [12]
  C.H. Heldin, K. Rubin, K. Pietras, et al., Nat. Rev. Cancer 4(2004) 806-813. doi: 10.1038/nrc1456
13. [13]
  H. Yang, Z. Tong, S. Sun, et al., J. Control. Release 328(2020) 28-44. doi: 10.1016/j.jconrel.2020.08.024
14. [14]
  H. Cabral, Y. Matsumoto, K. Mizuno, et al., Nat. Nanotechnol. 6(2011) 815-823. doi: 10.1038/nnano.2011.166
15. [15]
  J.G. Dancy, A.S. Wadajkar, C.S. Schneider, et al., J. Control. Release 238(2016) 139-148. doi: 10.1016/j.jconrel.2016.07.034
16. [16]
  G. Kibria, H. Hatakeyama, N. Ohga, et al., Biomaterials 34(2013) 5617-5627. doi: 10.1016/j.biomaterials.2013.03.094
17. [17]
  K.L. Lee, L.C. Hubbard, S. Hern, et al., Biomater. Sci. 1(2013) 581-588. doi: 10.1039/c3bm00191a
18. [18]
  R. Agarwal, P. Jurney, M. Raythatha, et al., Adv. Healthc. Mater. 4(2015) 2269-2280. doi: 10.1002/adhm.201500441
19. [19]
  C.Y. Tay, M.I. Setyawati, D.T. Leong, ACS Nano 11(2017) 2764-2772. doi: 10.1021/acsnano.6b07806
20. [20]
  M. Yu, L. Xu, F. Tian, et al., Nat. Commun. 9(2018) 2607. doi: 10.1038/s41467-018-05061-3
21. [21]
  H. Wu, M. Yu, Y. Miao, et al., Acta Pharm. Sin. B 9(2019) 858-870. doi: 10.1016/j.apsb.2019.02.010
22. [22]
  R. Liu, Y. An, W. Jia, et al., J. Control. Release 321(2020) 589-601. doi: 10.1016/j.jconrel.2020.02.043
23. [23]
  C. Lin, F. Tong, R. Liu, et al., Acta Pharm. Sin. B 10(2020) 2348-2361. doi: 10.1016/j.apsb.2020.10.009
24. [24]
  W. Xiao, H. Gao, Int. J. Pharm. 552(2018) 328-339. doi: 10.1016/j.ijpharm.2018.10.011
25. [25]
  H. Gao, Q. He, Expert Opin, Drug Deliv. 11(2014) 409-420.
26. [26]
  Y. Liu, Y. Huo, L. Yao, et al., Nano Lett. 19(2019) 8010-8020. doi: 10.1021/acs.nanolett.9b03211
27. [27]
  M. Zhang, X. Chen, C. Li, et al., J. Control. Release 319(2020) 46-62. doi: 10.1016/j.jconrel.2019.12.024
28. [28]
  M. Jin, G. Jin, L. Kang, et al., Int. J. Nanomedicine 13(2018) 2405-2426. doi: 10.2147/IJN.S161426
29. [29]
  A.J. Primeau, A. Rendon, D. Hedley, et al., Clin. Cancer Res. 11(2005) 8782-8788. doi: 10.1158/1078-0432.CCR-05-1664
30. [30]
  R. Tsumura, S. Manabe, H. Takashima, et al., J. Control. Release 284(2018) 49-56. doi: 10.1016/j.jconrel.2018.06.016
31. [31]
  L. Miao, J.M. Newby, C.M. Lin, et al., ACS Nano 10(2016) 9243-9258. doi: 10.1021/acsnano.6b02776
32. [32]
  E. Nance, C. Zhang, T.Y. Shih, et al., ACS Nano 8(2014) 10655-10664. doi: 10.1021/nn504210g
33. [33]
  W. Xiao, S. Ruan, W. Yu, et al., Mol. Pharm. 14(2017) 3489-3498. doi: 10.1021/acs.molpharmaceut.7b00475
34. [34]
  R. Liu, C. Hu, Y. Yang, et al., Acta Pharm. Sin. B 9(2019) 410-420. doi: 10.1016/j.apsb.2018.09.001
35. [35]
  Q. Zhou, S. Shao, J. Wang, et al., Nat. Nanotechnol. 14(2019) 799-809. doi: 10.1038/s41565-019-0485-z
36. [36]
  Y. Wang, Y. Xie, K.V. Kilchrist, et al., ACS Appl. Mater. Interfaces 12(2020) 4308-4322. doi: 10.1021/acsami.9b21214
37. [37]
  Z. Guo, B. He, H. Jin, et al., Biomaterials 35(2014) 6106-6117. doi: 10.1016/j.biomaterials.2014.04.031
38. [38]
  J.D. Martin, G. Seano, R.K. Jain, Annu. Rev. Physiol. 81(2019) 505-534. doi: 10.1146/annurev-physiol-020518-114700
39. [39]
  D. Wang, J. Fu, Y. Shi, et al., J. Control. Release 238(2016) 186-196. doi: 10.1016/j.jconrel.2016.07.014
40. [40]
  X. Sui, Y. Xu, X. Wang, et al., Mol. Pharm. 12(2015) 3783-3791. doi: 10.1021/acs.molpharmaceut.5b00577
41. [41]
  F.A. Duca, C.D. Cote, B.A. Rasmussen, et al., Nat. Med. 21(2015) 506-511. doi: 10.1038/nm.3787
42. [42]
  S.M.A. Da, J. Abarca-Quinones, B. Guigas, et al., Clin. Sci. 118(2009) 411-420.
43. [43]
  H. Han, Y. Hou, X. Chen, et al., J. Am. Chem. Soc. 142(2020) 4944-4954. doi: 10.1021/jacs.0c00650
44. [44]
  Y. Chen, W. Song, L. Shen, et al., ACS Nano 13(2019) 1751-1763.
45. [45]
  X. Cun, S. Ruan, J. Chen, et al., Acta Biomater. 31(2016) 186-196. doi: 10.1016/j.actbio.2015.12.002
46. [46]
  T. Jiang, B. Zhang, S. Shen, et al., ACS Appl. Mater. Interfaces 9(2017) 31497-31508. doi: 10.1021/acsami.7b09458
47. [47]
  W. Yu, M. Shevtsov, X. Chen, et al., Chin. Chem. Lett. 31(2020) 1366-1374. doi: 10.1016/j.cclet.2020.02.036
48. [48]
  W. Yu, R. Liu, Y. Zhou, et al., ACS Cent. Sci. 6(2020) 100-116. doi: 10.1021/acscentsci.9b01139
49. [49]
  Z. Shi, Q. Li, L. Mei, Chin. Chem. Lett. 31(2020) 1345-1356. doi: 10.1016/j.cclet.2020.03.001
50. [50]
  R. Liu, M. Yu, X. Yang, et al., Adv. Funct. Mater. 29(2019) 1808462. doi: 10.1002/adfm.201808462
51. [51]
  S. Ruan, X. Cao, X. Cun, et al., Biomaterials 60(2015) 100-110. doi: 10.1016/j.biomaterials.2015.05.006
52. [52]
  Z. Luo, Y. Dai, H. Gao, Acta Pharm. Sin. B 9(2019) 1099-1112. doi: 10.1016/j.apsb.2019.06.004
53. [53]
  W. Yu, X. He, Z. Yang, et al., Biomaterials 217(2019) 119309. doi: 10.1016/j.biomaterials.2019.119309
54. [54]
  C. Hu, T. Lei, Y. Wang, et al., Biomaterials 255(2020) 120159. doi: 10.1016/j.biomaterials.2020.120159
55. [55]
  X. Xiong, Z. Xu, H. Huang, et al., Biomaterials 245(2020) 119840. doi: 10.1016/j.biomaterials.2020.119840
56. [56]
  S. Ruan, C. Hu, X. Tang, et al., ACS Nano 10(2016) 10086-10098. doi: 10.1021/acsnano.6b05070
57. [57]
  S. Ruan, W. Xiao, C. Hu, et al., ACS Appl. Mater. Interfaces 9(2017) 20348-20360. doi: 10.1021/acsami.7b02303
58. [58]
  W. Yu, C. Hu, H. Gao, ACS Appl Bio Mater 3(2020) 5455-5462. doi: 10.1021/acsabm.0c00917
59. [59]
  L. Wang, W. Jiang, L. Xiao, et al., ACS Nano 14(2020) 8459-8472. doi: 10.1021/acsnano.0c02674
60. [60]
  Z. Cong, L. Zhang, S.Q. Ma, et al., ACS Nano 14(2020) 1958-1970. doi: 10.1021/acsnano.9b08434
61. [61]
  E. Ruoslahti, Adv. Mater. 24(2012) 3747-3756. doi: 10.1002/adma.201200454
62. [62]
  K.N. Sugahara, T. Teesalu, P.P. Karmali, et al., Science 328(2010) 1031-1035. doi: 10.1126/science.1183057
63. [63]
  X. Cun, J. Chen, S. Ruan, et al., ACS Appl. Mater. Interfaces 7(2015) 27458-27466. doi: 10.1021/acsami.5b09391
64. [64]
  X. Yang, X. Chen, T. Lei, et al., Acta Pharm. Sin. B 10(2020) 1094-1105. doi: 10.1016/j.apsb.2020.02.011
65. [65]
  J. Zhao, B. Wen, Z. Tan, et al., J. Drug Target. 28(2020) 1063-1070. doi: 10.1080/1061186X.2020.1775839
66. [66]
  S. Zhang, X. Pei, H. Gao, et al., Chin. Chem. Lett. 31(2020) 1060-1070. doi: 10.1016/j.cclet.2019.11.036
67. [67]
  C. Hu, X. Cun, S. Ruan, et al., Biomaterials 168(2018) 64-75. doi: 10.1016/j.biomaterials.2018.03.046
68. [68]
  C. Hu, X. Yang, R. Liu, et al., ACS Appl. Mater. Interfaces 10(2018) 22571-22579. doi: 10.1021/acsami.8b04847
69. [69]
  L. Cai, C. Yang, W. Jia, et al., Adv. Funct. Mater. 30(2020) 1909999. doi: 10.1002/adfm.201909999
70. [70]
  S. Ruan, L. Qin, W. Xiao, et al., Adv. Funct. Mater. 28(2018) 1802227. doi: 10.1002/adfm.201802227
71. [71]
  Y. Jin, Z. Wu, C. Wu, et al., J. Control. Release 320(2020) 142-158. doi: 10.1016/j.jconrel.2020.01.040
72. [72]
  Y. Sakurai, T. Hada, S. Yamamoto, et al., Mol. Ther. 24(2016) 2090-2099. doi: 10.1038/mt.2016.178
73. [73]
  M.L. Tang, X.J. Bai, Y. Li, et al., Curr. Med. Sci. 38(2018) 809-817. doi: 10.1007/s11596-018-1947-5
1. [1]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
2. [2]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
3. [3]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
4. [4]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
5. [5]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
6. [6]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
7. [7]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
8. [8]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
9. [9]
  Zhendong Liu , Sainan Liu , Bin Liu , Qi Meng , Meng Yuan , Chunzheng Yang , Yulong Bian , Ping'an Ma , Jun Lin . Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy. Chinese Chemical Letters, 2024, 35(11): 109626-. doi: 10.1016/j.cclet.2024.109626
10. [10]
  Yunkang Tong , Haiqiao Huang , Haolan Li , Mingle Li , Wen Sun , Jianjun Du , Jiangli Fan , Lei Wang , Bin Liu , Xiaoqiang Chen , Xiaojun Peng . Cooperative bond scission by HRP/H₂O₂ for targeted prodrug activation. Chinese Chemical Letters, 2024, 35(12): 109663-. doi: 10.1016/j.cclet.2024.109663
11. [11]
  Jiahao Liu , Peng Liu , Junhong Duan , Qiongxuan Xie , Jie Feng , Hongpei Tan , Ze Mi , Ying Li , Yunjie Liao , Pengfei Rong , Wenhu Zhou , Xiang Gao . Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy. Chinese Chemical Letters, 2024, 35(12): 109632-. doi: 10.1016/j.cclet.2024.109632
12. [12]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
13. [13]
  Yixin Zhang , Ting Wang , Jixiang Zhang , Pengyu Lu , Neng Shi , Liqiang Zhang , Weiran Zhu , Nongyue He . Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chinese Chemical Letters, 2024, 35(4): 108619-. doi: 10.1016/j.cclet.2023.108619
14. [14]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
15. [15]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
16. [16]
  Fereshte Hassanzadeh-Afruzi , Mina Azizi , Iman Zare , Ehsan Nazarzadeh Zare , Anwarul Hasan , Siavash Iravani , Pooyan Makvandi , Yi Xu . Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing. Chinese Chemical Letters, 2024, 35(11): 109564-. doi: 10.1016/j.cclet.2024.109564
17. [17]
  Shenglan Zhou , Haijian Li , Hongyi Gao , Ang Li , Tian Li , Shanshan Cheng , Jingjing Wang , Jitti Kasemchainan , Jianhua Yi , Fengqi Zhao , Wengang Qu . Recent advances in metal-loaded MOFs photocatalysts: From single atom, cluster to nanoparticle. Chinese Chemical Letters, 2025, 36(1): 110142-. doi: 10.1016/j.cclet.2024.110142
18. [18]
  Lishan Xiong , Xinyuan Li , Xiaojie Lu , Zhendong Zhang , Yan Zhang , Wen Wu , Chenhui Wang . Inhaled multilevel size-tunable, charge-reversible and mucus-traversing composite microspheres as trojan horse: Enhancing lung deposition and tumor penetration. Chinese Chemical Letters, 2024, 35(9): 109384-. doi: 10.1016/j.cclet.2023.109384
19. [19]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
20. [20]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(645)
HTML views(107)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142