Citation: Xiao Fu, Guiqiang Zhang, Yulin Zhang, Haifeng Sun, Shuang Yang, Shilei Ni, Jiwei Cui. Co-delivery of anticancer drugs and cell penetrating peptides for improved cancer therapy[J]. Chinese Chemical Letters, ;2021, 32(4): 1559-1562. doi: 10.1016/j.cclet.2020.10.011 shu

Co-delivery of anticancer drugs and cell penetrating peptides for improved cancer therapy

Xiao Fu ^a ,
Guiqiang Zhang ^a ,
Yulin Zhang ^b ,
Haifeng Sun ^a ,
Shuang Yang ^a ,
Shilei Ni ^b ,
Jiwei Cui ^{a, c, *,}

a.
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, China
b.
Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China
c.
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China

jwcui@sdu.edu.cn

Received Date: 31 July 2020
Revised Date: 9 October 2020
Accepted Date: 10 October 2020
Available Online: 12 October 2020

Figures(5)

Delivery systems based on nanoparticles (NPs) have shown great potential to reduce side effects and improve the therapeutic efficacy. Herein, we report the one-pot synthesis of poly(ethylene glycol)-mediated zeolitic imidazolate framework-8 (ZIF-8) NPs for the co-delivery of an anticancer drug (i.e., doxorubicin) and a cell penetrating peptide containing histidine and arginine (i.e., H4R4) to improve the efficacy of therapeutic delivery. The cargo-encapsulated ZIF-8 NPs are pH-responsive, which are stable at neutral pH and degradable at acidic pH to release the encapsulated cargos. The released H4R4 can help for endosome/lysosome escape to enhance the cytotoxicity of the encapsulated drugs. In vivo studies demonstrate that the co-delivery of doxorubicin and H4R4 peptides can efficiently inhibit tumor growth without significant side effects. The reported strategy provides a new perspective on the design of drug delivery systems and brings more opportunities for biomedical applications.
- Metal-organic frameworks,
- Lysosome escape,
- pH-responsiveness,
- Drug delivery,
- Poly(ethylene glycol)
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