Citation: Zhihao Feng, Zhaogang Teng, Yuyuan Shi, Wenhui Shi, Xiaodan Su, Guangming Lu, Lianhui Wang, Lixing Weng. Deformable double-shelled hollow mesoporous organosilica nanocapsules: A multi-interfacial etching strategy[J]. Chinese Chemical Letters, ;2021, 32(3): 1101-1105. doi: 10.1016/j.cclet.2020.08.023 shu

Deformable double-shelled hollow mesoporous organosilica nanocapsules: A multi-interfacial etching strategy

Zhihao Feng ^a ,
Zhaogang Teng ^{a, *,} ,
Yuyuan Shi ^b ,
Wenhui Shi ^a ,
Xiaodan Su ^a ,
Guangming Lu ^c ,
Lianhui Wang ^{a, *,} ,
Lixing Weng ^b

a.
Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications (NJUPT), Nanjing 210023, China
b.
College of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, China
c.
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China

iamzgteng@njupt.edu.cn

lxweng@njupt.edu.cn

Received Date: 25 June 2020
Revised Date: 29 July 2020
Accepted Date: 31 July 2020
Available Online: 22 August 2020

Figures(4)

Multishelled hollow structures have drawn increasing interest because of their peculiar compartmentation environments and physicochemical properties. In this work, deformable double-shelled hollow mesoporous organosilica nanocapsules (DDHMONs) were successfully synthesized by a multi-interfacial etching strategy. The obtained DDHMONs have a double-shelled structure with aninorganic-organic hybrid framework, a uniform outer layer (~320 nm) and inner layer (~180 nm), ordered mesochannels (~2.21 nm), and a large specific surface area (~1233 m²/g). In vitro toxicity tests show that the DDHMONs have excellent biocompatibility when coincubated with human breast cancer cells. In addition, the anticancer substance doxorubicin (DOX) can be highly loaded in DDHMONs (~335 μg/mg). The results from flow cytometry together with confocal laser scanning microscopy show that DOX can be efficiently delivered into MCF-7 cells by DDHMONs, thus improving chemotherapeutic efficiency and demonstrating that DDHMONs have potential nanomedicine applications as anticancer agents.
- Hollow structure,
- Mesoporous,
- Double-shelled,
- Organosilica,
- Anticancer
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沈阳化工大学材料科学与工程学院沈阳 110142