Citation: Yiyun Gao, Yan Gao, Yuanfu Ding, Huaping Tan, Aihua Zou, Shengke Li. Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils[J]. Chinese Chemical Letters, ;2021, 32(3): 949-953. doi: 10.1016/j.cclet.2020.08.010 shu

Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils

Yiyun Gao ^{a, b, 1} ,
Yan Gao ^{c, 1} ,
Yuanfu Ding ^c ,
Huaping Tan ^a ,
Aihua Zou ^{b, d, **,} ,
Shengke Li ^{a, *,}

a.
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
b.
Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
c.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
d.
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China

Author Bio:

Shengke Li received MSc degree in Organic Chemistry from East China University of Science and Technology in 2012. After three years working as a Chemist in cosmetic industry, he joined University of Macau to pursue pH.D. degree in Biomedical Sciences under the supervision of Professor Ruibing Wang in 2015. Since then, he focused on pharmaceutical applications of cucurbituril-based hostguest chemistry. After graduation in 2018, he joined Nanjing University of Science and Technology as a Lecturer and continued his research on supramolecular biomaterials based on cucurbiturils and their derivatives

^**

aihuazou@ecust.edu.cn

lisk@njust.edu.cn

Received Date: 19 June 2020
Revised Date: 7 August 2020
Accepted Date: 10 August 2020
Available Online: 14 August 2020

Figures(4)

With excellent biocompatibility and biodegradability, natural polysaccharides and their derivatives have exhibited great potential in constructing drug delivery vehicles for tissue engineering and therapeutics. Cucurbit[n]uril (CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuli-responsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-responsive drug release by incorporation with other stimuli including photo, redox, and enzyme. Through host-guest interactions between CB[6] and aliphatic diamines, functional tags covalently connected with CB[6] can be readily anchored into polysaccharide-based hydrogels, realizing multiple functionalization. The rheological property and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dynamic homo or hetero crosslinking of polysaccharides and/or other polymers. In this review, we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6] and CB[8], covering both bulk hydrogels and particular systems. At the end, possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed.
- Cucurbit[n]uril,
- Host-guest interaction,
- Polysaccharides,
- Hydrogel,
- Drug delivery,
- Tissue engineering
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