Citation: Yupeng Jiao, Shang Lan, Da Ma. Ultra-stable and multistimuli-responsive nanoparticles coated with zwitterionic pillar[n]arene for enhanced cellular uptake[J]. Chinese Chemical Letters, ;2021, 32(3): 1025-1028. doi: 10.1016/j.cclet.2020.08.001 shu

Ultra-stable and multistimuli-responsive nanoparticles coated with zwitterionic pillar[n]arene for enhanced cellular uptake

Department of Chemistry, Fudan University, Shanghai 200433, China

dama@fudan.edu.cn

Received Date: 19 June 2020
Revised Date: 13 July 2020
Accepted Date: 4 August 2020
Available Online: 6 August 2020

Figures(6)

Nanoparticle surface property is crucial for circulation stability, cellullar uptake and other biological characteristics. Zwitterionic pillar[n]arenes (ZPns) were used to coat gold nanoparticles (GNPs) via host-guest interaction. The resulting GNPs demonstrated higher stability in blood serum compared to polyethylene glycol (PEG)-coated GNPs. ZPn-coated GNPs were responsive to UV-irradiation, competitive displacement and acidic pH. UV-irradiation or competitive displacement could lead to the removal of ZPn coating to expose GNPs, which enhanced cell uptake efficiency by 5.9- and 7.4-fold, respectively.
- Host-guest systems,
- Stimuli responsiveness,
- Zwitterionic ligands,
- Gold nanoparticles,
- Cellular uptake
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