Citation: Min Liu, Haiying Zhao, Changkun Li. Rh(Ⅰ)-catalyzed regio- and enantioselective allylic alkylation of Meldrum's acid[J]. Chinese Chemical Letters, ;2021, 32(1): 385-388. doi: 10.1016/j.cclet.2020.04.009 shu

Rh(Ⅰ)-catalyzed regio- and enantioselective allylic alkylation of Meldrum's acid

Min Liu ^a ,
Haiying Zhao ^{a, *,} ,
Changkun Li ^{b, *,}

a.
Inner Mongolia Key Laboratory of Fine Organic Synthesis, College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China
b.
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

hyzhao@imu.edu.cn

chkli@sjtu.edu.cn

Received Date: 24 March 2020
Revised Date: 30 March 2020
Accepted Date: 6 April 2020
Available Online: 14 April 2020

Figures(5)

A Rh(Ⅰ)-catalyzed highly regio- and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed. The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities. This method provides a rapid access to various chiral β-alkyl-λ, δ-unsaturated carboxylic acids and their derivatives.
- Rhodium,
- Bisoxazolinephosphine,
- Allylic substitution,
- Meldrum's acid,
- Asymmetric catalysis
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