Citation: Shi Zhaoqing, Li Qianqian, Mei Lin. pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy[J]. Chinese Chemical Letters, ;2020, 31(6): 1345-1356. doi: 10.1016/j.cclet.2020.03.001 shu

pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy

Shi Zhaoqing ^a ,
Li Qianqian ^a ,
Mei Lin ^a,b,*,

a.
School of Pharmaceutical Sciences(Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
b.
Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China

meilin7@mail.sysu.edu.cn

Received Date: 19 January 2020
Revised Date: 22 February 2020
Accepted Date: 1 March 2020
Available Online: 2 March 2020

Figures(7)

Cancer is one of the diseases that have the highest mortality, which threatens the human health. Chemotherapy functions as the most widely used strategy in clinic to treat cancer, still exists urgent problems, like lacking selectivity and causing severe side effects. According to detailed researches on the metabolism, functions and histology of cancer tissues, many different features of cancer are uncovered, like lower pH in microenvironment, abnormal redox level in intracellular compartments and elevated expression level of several enzymes and receptors. Recently, the development of smart nanoparticles that response to tumor specific microenvironment has lighted up hope for selective cancer therapy. Herein, this review mainly focuses on pH-sensitive nanoscale materials for anti-cancer drug delivery. We summarized the formation progress of acidic tumor microenvironment, the mechanism of pH-responsive drug delivery system and nanomaterials that responsive to acidic pH in tumor microenvironment.
- Cancer therapy,
- Drug delivery systems,
- Nanoparticles,
- pH-sensitive material
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沈阳化工大学材料科学与工程学院沈阳 110142