Citation: Huang Yixing, Yu Xingfang, He Linjie, Liao Xin, Wang Shuo, Qian Zhiyong, Shen Liyan. 3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering[J]. Chinese Chemical Letters, ;2020, 31(7): 1797-1800. doi: 10.1016/j.cclet.2020.01.039 shu

3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering

Huang Yixing ^a ,
Yu Xingfang ^a ,
He Linjie ^a ,
Liao Xin ^a ,
Wang Shuo ^b,*, ,
Qian Zhiyong ^c,*, ,
Shen Liyan ^a,*,

a.
Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China
b.
College of Pharmacy, Zhejiang Pharmaceutical College, Ningbo 315199, China
c.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China

16140817@qq.com

anderson-qian@163.com

shenliyan@wmu.edu.cn

Received Date: 16 December 2019
Revised Date: 10 January 2020
Accepted Date: 17 January 2020
Available Online: 18 January 2020

Figures(4)

Acellular tissue matrix scaffolds are much closer to tissue's complex natural structure and biological characteristics, thus assess great advantages in cartilage engineering. We used rabbit costal cartilage to prepare acellular microfilaments and further 3D porous acellular cartilage scaffold via crosslinking. Poly (L-lysine)/hyaluronic acid (PLL/HA) multilayer film was then built up onto the surface of the resulting porous scaffold. Furthermore, TGF-β3 was loaded into the PLL/HA multilayer film coated scaffold to obtain a 3D porous acellular cartilage scaffold with sustained releasing of TGF-β3 up to 60 days. The success of this project will provide a new way for the treatment of articular cartilage defects. Meanwhile, the anchoring and on-site sustained releasing of growth factors mediated by polyelectrolyte multilayered film can also provide a new method for improving the biocompatibility and the biofunctionality for other implanted biomaterials.
- Acellular cartilage matrix scaffold,
- TGF-β3,
- Polyelectrolyte multilayer film,
- Sustainable release
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