Citation: Fang Xin, Ma Qiang, Feng Yi, Liang Shuang. (±)-6-3'a, 7-6'-Isowallichilide: A pair of enantiomeric phthalide dimers from Ligusticum chuanxiong with new 6-3'a, 7-6' dimerization sites[J]. Chinese Chemical Letters, ;2020, 31(5): 1251-1253. doi: 10.1016/j.cclet.2019.12.012 shu

(±)-6-3'a, 7-6'-Isowallichilide: A pair of enantiomeric phthalide dimers from Ligusticum chuanxiong with new 6-3'a, 7-6' dimerization sites

Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

ls7312@163.com

Received Date: 15 October 2019
Revised Date: 2 December 2019
Accepted Date: 4 December 2019
Available Online: 5 December 2019

Figures(2)

(+)-6-3'a, 7-6'-Isowallichilide and (-)-6-3'a, 7-6'-isowallichilide, a pair of enantiomeric phthalide dimers featuring new 6-3'a, 7-6' dimerization sites, were isolated from Ligusticum chuanxiong. The structures were elucidated by NMR spectroscopy and X-ray diffraction analysis. Furthermore, the absolute configurations were assigned using experimental and theoretical electronic circular dichroism methods. Their nitric oxide inhibition, antiplatelet aggregation and antioxidant activities were investigated.
- Ligusticum chuanxiong,
- Phthalide dimers,
- Enantiomers,
- Dimerization sites
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沈阳化工大学材料科学与工程学院沈阳 110142