Citation: Zhu Qiwen, Saeed Madiha, Song Rundi, Sun Tao, Jiang Chen, Yu Haijun. Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy[J]. Chinese Chemical Letters, ;2020, 31(5): 1051-1059. doi: 10.1016/j.cclet.2019.12.002 shu

Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy

Zhu Qiwen ^a ,
Saeed Madiha ^a ,
Song Rundi ^a ,
Sun Tao ^b ,
Jiang Chen ^b ,
Yu Haijun ^a,c,*,

a.
State Key Laboratory of Drug Research&Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
b.
Key Laboratory of Smart Drug Delivery(Ministry of Education), State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China

hjyu@simm.ac.cn

Received Date: 1 October 2019
Revised Date: 29 November 2019
Accepted Date: 2 December 2019
Available Online: 3 December 2019

Figures(10)

Drug delivery systems (DDSs) are of paramount importance to deliver drugs at the intended targets, e.g., tumor cells or tissue by prolonging blood circulation and optimizing the pharmaceutical profiles. However, the therapeutic efficacy of DDSs is severely impaired by insufficient or non-specific drug release. Dynamic chemical bonds having stimuli-liable properties are therefore introduced into DDSs for regulating the drug release kinetics. This review summarizes the recent advances of dynamic covalent chemistry in the DDSs for improving cancer therapy. The review discusses the constitutions of the major classes of dynamic covalent bonds, and the respective applications in the tumor-targeted DDSs which are based on the different responsive mechanisms, including acid-activatable and reduction-activatable. Furthermore, the review also discusses combination strategies of dual dynamic covalent bonds which can response to the complex tumor microenvironment much more accurately, and then summarizes and analyzes the prospects for the application of dynamic covalent chemistry in DDSs.
- Cancer therapy,
- Drug delivery systems,
- Dynamic covalent chemistry,
- Acid-responsive,
- Reduction-responsive
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沈阳化工大学材料科学与工程学院沈阳 110142