Citation: Jia Xinyu, Wu Yongmei, Lei Chun, Yu Yanyan, Li Jianqi, Li Jingya, Hou Aijun. Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum[J]. Chinese Chemical Letters, ;2020, 31(5): 1263-1266. doi: 10.1016/j.cclet.2019.10.014 shu

Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum

Jia Xinyu ^a,c ,
Wu Yongmei ^b ,
Lei Chun ^a ,
Yu Yanyan ^b ,
Li Jianqi ^c,*, ,
Li Jingya ^b,*, ,
Hou Aijun ^a,*,

a.
School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China
b.
National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
c.
Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China

lijianqb@126.com

jyli@simm.ac.cn

ajhou@shmu.edu.cn

Received Date: 21 August 2019
Revised Date: 13 October 2019
Accepted Date: 14 October 2019
Available Online: 30 October 2019

Figures(7)

Hyperinoids A (1) and B (2), two prenylated acylphloroglucinol related meroterpenoids, were isolated from Hypericum patulum. Compound 1 incorporates an unprecedented 11, 12-dioxatetracyclo[5.4.3.0^{1, 7}.0^{4, 14}]tetradecane system, while 2 possesses a unique 10, 11-dioxatetracyclo[5.3.3.0^{1, 7}.0^{4, 13}] tridecane system. Their structures were established by spectroscopic analysis and X-ray crystallographic data. Compounds 1 and 2 were identified as potent NF-κB inhibitors and suppressed the LPS-induced inflammatory responses in RAW 246.7 macrophages and primary mouse BMDM cells
- Meroterpenoids,
- Hyperinoids A and B,
- Anti-inflammation,
- Hypericum patulum,
- Guttiferae
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