Citation: Li Chaojie, Wang Yaping, Lu Yulin, Guo Jing, Zhu Chengyi, He Haozhe, Duan Xiaohui, Pan Mei, Su Chengyong. An iridium(Ⅲ)-palladium(Ⅱ) metal-organic cage for efficient mitochondria-targeted photodynamic therapy[J]. Chinese Chemical Letters, ;2020, 31(5): 1183-1187. doi: 10.1016/j.cclet.2019.09.034 shu

An iridium(Ⅲ)-palladium(Ⅱ) metal-organic cage for efficient mitochondria-targeted photodynamic therapy

Li Chaojie ^a,1 ,
Wang Yaping ^a,1 ,
Lu Yulin ^a ,
Guo Jing ^a ,
Zhu Chengyi ^a ,
He Haozhe ^b ,
Duan Xiaohui ^c ,
Pan Mei ^a,*, ,
Su Chengyong ^a

a.
MOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
b.
School of Materials Science and Engineering and School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
c.
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

panm@mail.sysu.edu.cn

Received Date: 2 August 2019
Revised Date: 11 September 2019
Accepted Date: 18 September 2019
Available Online: 18 September 2019

Figures(4)

An Ir₈Pd₄-heteronuclear metal-organic cage (MOC-51) was assembled from bipodal metalloligand[Ir(ppy)₂(qpy)(BF₄)] (qpy=4, 4':2', 2":4", 4"'-quaterpyridine; ppy=2-phenylpridine) with Pd(Ⅱ) salt. The cubic barrel shaped MOC shows one-photon and two-photon excited deep-red emission, as well as large singlet oxygen quantum yields under visible light irradiation, therefore exhibiting great potentials in organelles-targeted cell imaging and photodynamic therapy (PDT). Compared with the Ir(Ⅲ) metalloligand, the Ir₈Pd₄-MOC showed less dark toxicity and higher mitochondria-targeting efficiency. The localization in mitochondria overcomes the limitation of short lifetime and diffusion distance of ROS in cell, thus improved PDT effect can be obtained in low light dose usage of the MOC. This study presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapy
- Metal-organic cage,
- Photodynamic therapy,
- Mitochondria-targeted,
- Ir(Ⅲ) metalloligand,
- Two-photon
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