Citation: Kong Linlin, Jin Xinyi, Hu Dapeng, Feng Leyun, Chen Dong, Li Hanying. Functional delivery vehicle of organic nanoparticles in inorganic crystals[J]. Chinese Chemical Letters, ;2019, 30(12): 2351-2354. doi: 10.1016/j.cclet.2019.08.007 shu

Functional delivery vehicle of organic nanoparticles in inorganic crystals

Kong Linlin ^a,b,1 ,
Jin Xinyi ^c,1 ,
Hu Dapeng ^c ,
Feng Leyun ^a ,
Chen Dong ^a,b,*, ,
Li Hanying ^c,**,

a.
Institute of Process Equipment, College of Energy Engineering, Zhejiang University, Hangzhou 310027, China
b.
State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China
c.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, State Key Laboratory of Silicon Materials, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

^**

chen_dong@zju.edu.cn

hanying_li@zju.edu.cn

Received Date: 19 June 2019
Revised Date: 21 July 2019
Accepted Date: 5 August 2019
Available Online: 6 December 2019

Figures(4)

Encapsulation of bioactive substances for extended shelf life and controlled, targeted release is critical for their applications in food and drug delivery. Here, a new method has been developed to encapsulate bioactive molecules in the crystal composites, showing greatly enhanced stability and unique pH-triggered response. Chlorophyll, a model bioactive, is first loaded in shellac nanoparticles via coprecipitation with a high encapsulation efficiency, and then the chlorophyll-loaded nanoparticles are incorporated into calcite crystals grown from a gel media containing the nanoparticles. Under the protection of shellac nanoparticles and calcite crystals, chlorophyll shows excellent stability even under light. Encapsulated chlorophyll could only be released by first dissolving the calcite crystals under acidic condition and then dissolving the shellac nanoparticles under alkaline condition. The unique pH-triggered release mimics the pH change from acidic in the stomach to alkaline in the intestine and is thus well suited for controlled, targeted intestinal release. This work suggests that the crystal composites are an ideal delivery vehicle for the functional design of bioactive molecules.
- Nanoparticle,
- Calcite crystal,
- Encapsulation,
- Chlorophyll,
- Dual-pH responses
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