Citation: Qi Xinzhu, Liu Jiabao, Chen Jiabao, Hou Qi, Li Shuai. New seco-dibenzocyclooctadiene lignans with nitric oxide production inhibitory activity from the roots of Kadsura longipedunculata[J]. Chinese Chemical Letters, ;2020, 31(2): 423-426. doi: 10.1016/j.cclet.2019.06.006 shu

New seco-dibenzocyclooctadiene lignans with nitric oxide production inhibitory activity from the roots of Kadsura longipedunculata

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

lishuai@imm.ac.cn

Received Date: 5 May 2019
Revised Date: 3 June 2019
Accepted Date: 4 June 2019
Available Online: 5 June 2019

Figures(5)

Four new seco-dibenzocyclooctadiene lignans, kadlongilignans A-D (1-4), consisting of a rare 6, 7-seco-(1), two 15, 16-seco-(2 and 3) and a 9, 10-seco-dibenzocyclooctadiene (4) lignans, were isolated from the roots of Kadsura longipedunculata. Their structures were elucidated by spectroscopic analysis, including extensive NMR, MS and ECD (electronic circular dichroism) spectra. Compounds 3 and 4 exhibited potent inhibitory activities against NO (nitric oxide) production of LPS (lipopolysaccharide)-induced murine macrophages with the inhibition rates of 36.3% and 26.9%, respectively.
- Kadsura longipedunculata,
- Seco-dibenzocyclooctadiene lignans,
- Kadlongilignans A-D,
- Spectroscopic analysis,
- NO production inhibition
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