Citation: Lan Weifei, Tan Qiqi, Qiao Juan, Shen Gangyi, Li Qi. D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed[J]. Chinese Chemical Letters, ;2019, 30(9): 1627-1630. doi: 10.1016/j.cclet.2019.05.019 shu

D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed

Lan Weifei ^a,d,1 ,
Tan Qiqi ^a,c,1 ,
Qiao Juan ^a,b ,
Shen Gangyi ^d ,
Li Qi ^a,b,*,

a.
Beijing National Laboratory of Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
c.
Department of Chemical Engineering, Beijing Institute of Petro-chemical Technology, Beijing 102617, China
d.
School of Pharmacy, Minzu University of China, Beijing 100081, China

qili@iccas.ac.cn

Received Date: 2 April 2019
Revised Date: 7 May 2019
Accepted Date: 7 May 2019
Available Online: 8 September 2019

Figures(5)

With D-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared (D-Pro@AuNCs) within 10 min at 100 ℃. In the present of gold nanoparticles, the fluorescence of D-Pro@AuNCs was remarkably quenched. Interestingly, based on the electrostatic interaction between anticancer drug Raltitrexed and gold nanoparticles induced fluorescence "turn-on" principle, a high selective assay for detection of Raltitrexed was established with the probe associating the fluorescence emission at 435 nm. The fluorescence intensity of D-Pro@AuNCs linearly correlated with the concentration of Raltitrexed in the range from 5.0 μmol/L to 40.0 μmol/L (R²=0.999) and the limit of detection was 1.9 μmol/L. Further, after Raltitrexed was abdominal injected in rats, a metabolic approach was constructed with the prepared fluorescent probe. It showed great potential of AuNCs-based sensing probes for application in analysis of serum anticancer drugs.
- D-Pro capped gold nanoclusters,
- Fluorescent probe,
- Turn on,
- Sensing,
- Serum RTX
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