Citation: Huang Erfang, Zhang Lan, Xiao Chuying, Meng Guangpeng, Zhang Bingqi, Hu Jianshu, Wan David Chi-Cheong, Meng Qingguo, Jin Zhe, Hu Chun. Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents[J]. Chinese Chemical Letters, ;2019, 30(12): 2157-2159. doi: 10.1016/j.cclet.2019.04.044 shu

Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents

a.
Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
c.
Department of Pharmacy, Yantai Univeristy, Yantai 264005, China

jinzheln@163.com

chunhu1999@163.com

Received Date: 27 February 2019
Revised Date: 15 April 2019
Accepted Date: 16 April 2019
Available Online: 17 December 2019

Figures(3)

Oxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted attention. In this paper, a novel series of indole-3-carboxamide derivatives (6a-6l) were designed and synthesized based on the melatonin structure as novel antioxidants. All of them were evaluated for the antioxidant activities in vitro against human neuroblastoma SH-SY5Y cell line using H₂O₂ radical scavenging assay. The target compounds 6a, 6f and 6i indicated better activities than the positive control, ascorbic acid, and 6a exhibited the best antioxidant activity. In addition, the structureactivity relationships of the target compounds were also preliminarily summarized based on the obtained experimental data.
- Heterocycle,
- Melatonin,
- Indole-3-carboxamide derivatives,
- Synthesis,
- Antioxidant activity,
- Structure-activity relationship
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1.
沈阳化工大学材料科学与工程学院沈阳 110142