Citation: Xue Wenting, Di Zhenghan, Zhao Ya, Zhang Aiping, Li Lele. DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells[J]. Chinese Chemical Letters, ;2019, 30(4): 899-902. doi: 10.1016/j.cclet.2019.03.022 shu

DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells

Xue Wenting ^a,b ,
Di Zhenghan ^b,c ,
Zhao Ya ^b ,
Zhang Aiping ^a,**, ,
Li Lele ^b,c,*,

a.
College of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
b.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China

_**

zhangap1@163.com

lilele@nanoctr.cn

Received Date: 28 February 2019
Revised Date: 7 March 2019
Accepted Date: 11 March 2019
Available Online: 15 April 2019

Figures(4)

superstructures has enormous potential in material sciences and engineering. Despite the potential, controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots (QDs) and lanthanide-doped upconversion nanoparticles (UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests.
- Bioimaging,
- Upconversion nanoparticles,
- Self-assembly,
- Quantum dots,
- Cancer targeting
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