Citation: Dang Bobo. Chemical synthesis and structure determination of venom toxins[J]. Chinese Chemical Letters, ;2019, 30(7): 1369-1373. doi: 10.1016/j.cclet.2019.03.021 shu

Chemical synthesis and structure determination of venom toxins

Dang Bobo ^a,b,*,

a.
School of Life Sciences, Westlake University, Hangzhou 310024, China
b.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou 310024, China

dangbobo@westlake.edu.cn

Received Date: 24 January 2019
Revised Date: 12 March 2019
Accepted Date: 14 March 2019
Available Online: 15 July 2019

Figures(7)

Venom toxins are widely spread in nature, adopting diverse structures and functions. They often function by blocking or modulating important membrane protein targets thus can be promising therapeutic candidates and biophysical probes. In this review, we briefly discuss the total chemical synthesis of venom toxins including the different refolding strategies reported during the past decade as well as innovative approaches for structure determination.
- Venom toxins,
- Chemical protein synthesis,
- Structure determination,
- Protein foldin,
- Racemic protein crystallography
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