Citation: Zhan Wei, Tong Meng, Ji Ling, Zhang Han, Ge Zemei, Wang Xin, Li Runtao. Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction[J]. Chinese Chemical Letters, ;2019, 30(5): 973-976. doi: 10.1016/j.cclet.2019.01.006 shu

Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

xinwang@bjmu.edu.cn

lirt@bjmu.edu.cn

Received Date: 13 December 2018
Revised Date: 2 January 2019
Accepted Date: 8 January 2019
Available Online: 9 May 2019

Figures(4)

A continuous-flow synthesis of nitriles by Schmidt reaction has been developed. Using this procedure, a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up.
- Continuous-flow reaction,
- Aldehydes,
- Schmidt reaction,
- Nitriles,
- Safety
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