Citation: Liu Meng, Li Zhihao, Li Yingxue, Chen Jiajia, Yuan Quan. Self-assembled nanozyme complexes with enhanced cascade activity and high stability for colorimetric detection of glucose[J]. Chinese Chemical Letters, ;2019, 30(5): 1009-1012. doi: 10.1016/j.cclet.2018.12.021 shu

Self-assembled nanozyme complexes with enhanced cascade activity and high stability for colorimetric detection of glucose

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

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Received Date: 23 October 2018
Revised Date: 16 December 2018
Accepted Date: 18 December 2018
Available Online: 18 May 2018

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Construction of multi-enzyme complexes not only can help expand the understanding of biological mechanisms, but also holds great promise in biosynthesis, biosensing and biomedicine. Herein, a hybrid multi-enzyme system, CeO₂/glucose oxidase (GOx) nanocomplex was developed via self-assembly and exhibited excellent catalytic activity toward cascade reactions. Compared to mixed GOx and CeO₂, the nanocomplexes displayed enhanced efficiency, mainly attributed to the minimal diffusion of intermediate in the nanocomplexes system. Moreover, the nanocomplexes exhibited outstanding long-term stability and excellent recyclability. Benefiting from these merits, a highly sensitive and selective biosensor for colorimetric detection of glucose was constructed based on CeO₂/GOx nanocomplexes. Such a self-assembled nanozyme complex offers a simple and efficient example to build spatially confined multi-enzyme systems to potentiate their applications in energy conversion, detoxification and bioanalysis
- Nanozyme,
- CeO₂,
- Cascade,
- Catalyze,
- Stability
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