Citation: Li Zhen, Liu Ting, Long Jimin, Wu Yang, Yan Biao, Ma Ping, Cao Yi. The toxicity of hydroxylated and carboxylated multi-walled carbon nanotubes to human endothelial cells was not exacerbated by ER stress inducer[J]. Chinese Chemical Letters, ;2019, 30(3): 582-586. doi: 10.1016/j.cclet.2018.12.011 shu

The toxicity of hydroxylated and carboxylated multi-walled carbon nanotubes to human endothelial cells was not exacerbated by ER stress inducer

Li Zhen ^a,b,1 ,
Liu Ting ^a,b,1 ,
Long Jimin ^b ,
Wu Yang ^a ,
Yan Biao ^a ,
Ma Ping ^a,*, ,
Cao Yi ^b,*,

a.
Laboratory of Environment-immunological and Neurological Diseases, School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning 437100, China
b.
Key Laboratory of Environment-Friendly Chemistry and Application of Ministry of Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan 411105, China

mping68@126.com

caoyi39@126.com

Received Date: 8 November 2018
Revised Date: 30 November 2018
Accepted Date: 7 December 2018
Available Online: 8 March 2018

Figures(7)

Hydroxylated multi-walled carbon nanotubes (h-MWCNTs) and carboxylated MWCNTs (c-MWCNTs) have potential applications in biomedicine, but their toxicity to human endothelial cells under stressed conditions associated with chronic diseases was less studied in vitro. This study stressed human umbilical vein endothelial cells (HUVECs) with ER stress inducer thapsigargin (TG), and investigated the toxicity of h-MWCNTs and c-MWCNTs to normal and stressed HUVECs. h-MWCNTs and c-MWCNTs modestly reduced cellular viability, significantly promoted soluble ICAM-1 (sICAM-1), soluble VCAM-1 (sVCAM-1) as well as intracellular ROS, and decreased the expression of transcription factor KLF2 and KLF4. Pre-treatment with TG significantly reduced cellular viability, promoted IL-6 and THP-1 monocyte adhesion, and increased the expression of a panel of ER stress genes. ANOVA indicated no interaction between MWCNTs and TG pre-treatment on most of the endpoints. It was concluded that the toxicity of h-MWCNTs and c-MWCNTs to HUVECs might not be exacerbated by ER stress inducer.
- Multi-walled carbon nanotubes (MWCNTs),
- Human umbilical vein endothelial cells (HUVECs),
- ER stress,
- Kruppel-like factor (KLF),
- Toxicity
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