Citation: Tao Chun, Yu Yue, Chen Zhenzhen, Zhang Minxin, Liu Linlin, Liu Zhihong, Zhang Jialiang, Zhang Qian, Song Hongtao. Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system[J]. Chinese Chemical Letters, ;2018, 29(12): 1849-1852. doi: 10.1016/j.cclet.2018.11.022 shu

Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system

Tao Chun ^a,1 ,
Yu Yue ^a,b,1 ,
Chen Zhenzhen ^a,b ,
Zhang Minxin ^a ,
Liu Linlin ^a ,
Liu Zhihong ^a ,
Zhang Jialiang ^a ,
Zhang Qian ^b,* ,
Song Hongtao ^a,*

a.
Department of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University(Fuzhou General Hospital), Fuzhou 350025, China
b.
College of Pharmacy, Fujian Medical University, Fuzhou 350108, China

pixiaprivate@126.com

sohoto@vip.163.com

Received Date: 10 October 2018
Revised Date: 7 November 2018
Accepted Date: 12 November 2018
Available Online: 20 December 2018

Figures(4)

To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system (SMEDDS), mesoporous silica nanospheres (MSNs) and Santa Barbara Amorphous-15 (SBA-15) were compared. The MSNs had hydrodynamic size of 195.35 ±5.82 nm, and pore diameter of 2.70 nm. The SBA-15 had hydrodynamic size of 2312.19 ±106.93 nm, and pore diameter of 10.91 nm. The MSNs and SBA-15 showed similar loading efficiency of SMEDDS containing sirolimus (SRL). However, MSNs had higher drug dissolution and in vivo absorption, with relative bioavailability of 174.62%. Thus, the length of mesopores played a more important role in solidification of SMEDDS as compared with the pore diameter. This study suggests that the SMEDDS-MSNs can be a potential candidate for oral administration of hydrophobic drugs.
- Mesopores,
- Mesoporous silica nanospheres,
- SBA-15,
- Self-microemulsifying drug delivery system,
- Sirolimus,
- Bioavailability
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