Citation: Zhang Letian, Liu Kun, Shao Xusheng, Li Zhong, Xu Xiaoyong. Synthesis and insecticidal bioactivities of 2, 3-dihydroimidazo[1,2-a]pyridin-5(1H)-one derivatives[J]. Chinese Chemical Letters, ;2019, 30(2): 340-344. doi: 10.1016/j.cclet.2018.09.012 shu

Synthesis and insecticidal bioactivities of 2, 3-dihydroimidazo[1,2-a]pyridin-5(1H)-one derivatives

Zhang Letian ^a ,
Liu Kun ^a ,
Shao Xusheng ^a ,
Li Zhong ^a,b ,
Xu Xiaoyong ^a,b,*,

a.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
b.
Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

xyxu@ecust.edu.cn

Received Date: 26 July 2018
Revised Date: 13 September 2018
Accepted Date: 14 September 2018
Available Online: 17 February 2018

Figures(3)

A novel synthesis of 2, 3-dihydroimidazo[1,2-a]pyridin-5(1H)-one 4 and its derivatives were described. Preliminary bioassays showed that some of the target compounds exhibited excellent insecticidal activities against brown planthopper (Nilaparvata lugens), cowpea aphids (Aphis craccivora) (4, 5a, 5c, 5g, 5h, 5j, 5r, 6b, 6e) and carmine spider mite (Tetranychus cinnabarinus (5f, 5s, 6a) at 500 mg/L. Among them, compound 4 was still active against brown planthopper and cowpea aphids at 4 mg/L. The insecticidal activities were influenced by the types and position of the substituents, which provided guidance for the structure modifications.
- Reaction selectivity,
- 2, 3-Dihydroimidazo[1,2-a]pyridin-5(1H)-one,
- Bicyclic pyridone,
- Insecticidal activities,
- Acaricidal activitiy
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