Citation: Chen Yu, Liu Lianchao, Wu Dimin, He Yu-Peng, Li Ang. A one-pot protocol for copper-mediated azide-alkyne cycloaddition using alkenyl triflate precursors[J]. Chinese Chemical Letters, ;2019, 30(1): 269-270. doi: 10.1016/j.cclet.2018.06.001 shu

A one-pot protocol for copper-mediated azide-alkyne cycloaddition using alkenyl triflate precursors

Chen Yu ^a,b,1 ,
Liu Lianchao ^b,1 ,
Wu Dimin ^b ,
He Yu-Peng ^a,, ,
Li Ang ^b,,

a.
College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, China
b.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Corresponding author: He Yu-Peng, yupeng.he@lnpu.edu.cn Li Ang, ali@sioc.ac.cn

Received Date: 12 April 2018
Revised Date: 1 June 2018
Accepted Date: 1 June 2018
Available Online: 1 January 2018

On the basis of the mild transformation of alkenyl triflates into alkynes promoted by LiCl, a one-pot protocol using alkenyl triflate precursors was developed for copper-mediated azide-alkyne cycloaddition. This protocol may provide an opportunity of sequentially click reactions for the construction of bifunctional probes in chemical biology studies.
- Click chemistry,
- Azide-alkyne cycloaddition,
- Alkenyl triflates,
- Lithium chloride
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