Citation: Liu Weijie, Li Jiao, He Kai, Huang Fangfang, Ma Yi, Li Yuxin, Li Qingshan, Xu Fengbo. Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives[J]. Chinese Chemical Letters, ;2019, 30(2): 417-420. doi: 10.1016/j.cclet.2018.05.023 shu

Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

qli@nankai.edu.cn

xufb@nankai.edu.cn

Received Date: 16 April 2018
Revised Date: 9 May 2018
Accepted Date: 11 May 2018
Available Online: 21 February 2018

Figures(4)

To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized. Bioassays indicated that all of the title compounds displayed 100% mortality against diamondback moth and oriental armyworm at 100 mg/L, among which 12v and 12w showed 100% insecticidal acitvity at 5 mg/L. Surprisingly compound 12w exhibited better insecticidal acitvity than commercialized chlorantraniliprole against Pyrausta nubilalis (0.1 mg/L) and Cnaphalocrocis Medinalis (2 mg/L). 3D-QSAR and SARs statistical analysis revealed that title compounds with R² fixed as methoxy had the highest probability possessing high activity. The calcium fluorescence measurements on neurons revealed that E series compounds containing pyrazinyl may have a molecular target different from caffeine on ryanodine receptors rather than the voltage-gated calcium channel present on cytomembran.
- Anthranilic diamide,
- Ryanodine receptor,
- Insecticide,
- Action mode,
- 3D-QSAR
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