Citation: Xu Tao-Tao, Li Jun-Hua, Cheng Fu-Rong, Zhang Yi-Xin, Cao Jun, Gao Wen-Xia, He Bin. Fabrication of a polypseudorotaxane nanoparticle with synergistic photodynamic and chemotherapy[J]. Chinese Chemical Letters, ;2017, 28(9): 1885-1888. doi: 10.1016/j.cclet.2017.07.029 shu

Fabrication of a polypseudorotaxane nanoparticle with synergistic photodynamic and chemotherapy

Xu Tao-Tao ^a ,
Li Jun-Hua ^a ,
Cheng Fu-Rong ^a ,
Zhang Yi-Xin ^b ,
Cao Jun ^a ,
Gao Wen-Xia ^c ,
He Bin ^a,,

a.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
b.
School of Chemical Engineering, Sichuan University, Chengdu 610065, China
c.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China

Corresponding author: He Bin, bhe@scu.edu.cn
Received Date: 28 April 2017
Revised Date: 25 July 2017
Accepted Date: 27 July 2017
Available Online: 29 September 2017

Figures(4)

A polypseudorotaxane (PPR) nanoparticle was fabricated by the self-assembly of mPEG-protoporphyrin IX (PpIX) conjugate and α-CDs via the host-guest interaction. The nanoparticle loaded with anticancer drug doxorubicin (DOX) exerted synergistic photodynamic and chemotherapy. The nanoparticle was spherical with the mean size of 89 nm, the low critical micelle concentration (CMC) of DOX-loaded nanoparticle was 9.3 μg/mL and the drug loading content was 9.93%. The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species (ROS) cytotoxicity and chemotherapeutic efficacy to cancer cells. The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.
- Polypseudorotaxane,
- Protoporphyrin IX,
- Photodynamic therapy,
- ROS,
- Chemotherapy
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