Citation: Zhang Zijie, Morishita Kiyoshi, David Lin Wei Ting, Jimmy Huang Po-Jung, Liu Juewen. Nucleotide coordination with 14 lanthanides studied by isothermal titration calorimetry[J]. Chinese Chemical Letters, ;2018, 29(1): 151-156. doi: 10.1016/j.cclet.2017.06.014 shu

Nucleotide coordination with 14 lanthanides studied by isothermal titration calorimetry

Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo N2L 3G1, Canada

Corresponding author: Liu Juewen, liujw@uwaterloo.ca

Received Date: 4 April 2017
Revised Date: 21 April 2017
Accepted Date: 7 June 2017
Available Online: 9 January 2017

Figures(5)

With their hydrolytic, optical and magnetic properties, lanthanide ions (Ln³⁺) are versatile probes for nucleic acids. In addition, nucleotide-coordinated Ln³⁺ ions form useful nanoparticles. However, the thermodynamic basis of their interaction is still lacking. In this work, isothermal titration calorimetry (ITC) is used to study the binding between nucleotides and 14 different Ln³⁺ ions. Ln³⁺ interacts mainly with the phosphate of cytidine and thymidine monophosphate (CMP and TMP), while the nucleobases in adenosine and guanosine monophosphate (AMP and GMP) are also involved. Phosphate binding is fully entropy driven since the reactions absorb heat. Nucleosides alone do not bind Ln³⁺ and the purines need the phosphate for chelation. With increasing atomic number of Ln³⁺, the binding reaction with GMP goes from exothermic to endothermic. The entropy contribution starts to increase from Gd³⁺, explaining the 'gadolinium break' observed in many Ln³⁺-mediated RNA cleavage reactions. This study provides fundamental insights into the Ln³⁺/nucleotide interactions, and it is useful for understanding related biosensors, nanomaterials, catalysts, and for lanthanide separation.
- DNA,
- Nucleic acids,
- Metal ions,
- Lanthanides,
- Entropy
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