Citation: Zhou Danni, Wang Chunxia, Li Mingliang, Long Zheng, Lan Jingbo. Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp³)-H activation and cyclization of aliphatic amides with gem-dibromoolefins: A rapid access to γ-lactams[J]. Chinese Chemical Letters, ;2018, 29(1): 191-193. doi: 10.1016/j.cclet.2017.06.007 shu

Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp³)-H activation and cyclization of aliphatic amides with gem-dibromoolefins: A rapid access to γ-lactams

Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China

Corresponding author: Lan Jingbo, jingbolan@scu.edu.cn
Received Date: 18 April 2017
Revised Date: 26 May 2017
Accepted Date: 2 June 2017
Available Online: 4 January 2017

Figures(4)

The direct Pd-catalyzed β-C(sp³)-H activation and cyclization of aliphatic amides bearing a removable 2-pyridylmethyl directing group with gem-dibromoolefins is described for the first time to construct a variety of γ-lactams. The resulting products with Z-and E-configurations can be easily separated and purified after the reaction, demonstrating the effectiveness and applicability of the method herein developed.
- C (sp³)-H activation,
- Palladium-catalyzed,
- gem-Dibromoolefins,
- Removable directing group,
- γ-Lactams
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沈阳化工大学材料科学与工程学院沈阳 110142

Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp3)-H activation and cyclization of aliphatic amides with gem-dibromoolefins: A rapid access to γ-lactams

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通讯作者: 陈斌, bchen63@163.com

Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp³)-H activation and cyclization of aliphatic amides with gem-dibromoolefins: A rapid access to γ-lactams