Citation: Yu Luodan, Chen Yu, Chen Hangrong. H₂O₂-responsive theranostic nanomedicine[J]. Chinese Chemical Letters, ;2017, 28(9): 1841-1850. doi: 10.1016/j.cclet.2017.05.023 shu

H₂O₂-responsive theranostic nanomedicine

Yu Luodan ^a,b ,
Chen Yu ^a,, ,
Chen Hangrong ^a,,

a.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China

Author Bio:
Yu Chen received his bachelor degree at Nanjing Tech University and PhD degree at Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS). He is now the full professor and Ph. D supervisor in SICCAS. His research includes the design, synthesis and biomedical applications of zero-dimensional organic-inorganic hybrid mesoporous materials, two-dimensional biomaterials and three-dimensional composite implants, including mesoporous material for drug delivery, planar nanosheets for theranostic nanomedicine, molecular probes for molecular imaging (MRI, CT, PA and US), ultrasound therapy, cardiac therapy, immunotherapy, non-virus gene delivery vehicles and in-situ localized tumor therapy. He has published more than 100 SCI papers in nanomedicine with more than 5500 citations (h-index 38).
Hangrong Chen received her Ph. D degree in Chinese Academy of Sciences in 2001. She is a full professor and Ph.D supervisor in Shanghai institute of Ceramics (SIC), Chinese Academy of Sciences (CAS), since 2006. Her recent research interest focuses on inorganic-based nanomaterials with mesoporous and/or specific structures for biomedicine or environmental catalytic application. She has published more than 200 SCI papers and 25 Chinese patents authorized. Her work has been cited for more than 7000 times by other scientists with h-index 47.
Corresponding author: Chen Yu, chenyu@mail.sic.ac.cn Chen Hangrong, hrchen@mail.sic.ac.cn(H.Chen)
Received Date: 18 April 2017
Revised Date: 19 May 2017
Accepted Date: 24 May 2017
Available Online: 1 October 2017

Figures(13)

The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and highperformance diagnosis and therapy of various diseases. Especially, H₂O₂-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H₂O₂ because H₂O₂ is associated with several kinds of human diseases as the most stable and abundant reactive oxygen species. This review summarizes and discusses the very-recent developments of H₂O₂-responsive theranostic nanoplatforms for versatile biomedical applications, including diagnostic imaging, attenuating tumor hypoxia, enhancing the therapeutic efficiency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/diabetic. The facing challenges and future developments of H₂O₂-responisve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic modality. It is highly believed that H₂O₂-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future.
- Hydrogen peroxide (H₂O₂),
- H₂O₂ responsibility,
- Stimuli-responsive,
- Nanomedicine,
- Theranostic
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

H2O2-responsive theranostic nanomedicine

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通讯作者: 陈斌, bchen63@163.com

H₂O₂-responsive theranostic nanomedicine