Citation: Li Qiwen, Liu Chenlu, Wen Junru, Wu Yongzhi, Shan Yue, Liao Jinfeng. The design, mechanism and biomedical application of self-healing hydrogels[J]. Chinese Chemical Letters, ;2017, 28(9): 1857-1874. doi: 10.1016/j.cclet.2017.05.007 shu

The design, mechanism and biomedical application of self-healing hydrogels

Li Qiwen ^a,1 ,
Liu Chenlu ^a,b,1 ,
Wen Junru ^a ,
Wu Yongzhi ^a ,
Shan Yue ^a ,
Liao Jinfeng ^a,,

a.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
Laboratory of Molecular and Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education at Sichuan University, West China Second University Hospital, Sichuan University, Chengdu 610061, China

Corresponding author: Liao Jinfeng, liaojinfeng.762@163.com

Received Date: 6 May 2017
Accepted Date: 8 May 2017
Available Online: 10 September 2017

Figures(14)

Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties, stimuli-responsiveness, biomimetic, and biocompatibility. However, the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used, especially in sophisticated in vivo environment. To address this problem, self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors. In this review, we focused on the current advances made in self-healing hydrogels. First, the testing methods for self-healing hydrogels were summarized. Then, we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism. What's more, the biomedical application of self-healing hydrogels in vivo was discussed.
- Self-healing,
- Hydrogels,
- Chemical mechanism,
- Biomaterials,
- In vivo
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沈阳化工大学材料科学与工程学院沈阳 110142