Citation: Zhao Hui, Hu Xiang-Guo, Xu Min-Jie, Cai Qun-Xing, Liu Yu-Jun, Su Duo-Meng, Chen Shi-Jin, Wang Kai, Gong Zhu-Nan. Six-step synthesis of Leonurine and toxicity study on zebrafish[J]. Chinese Chemical Letters, ;2017, 28(6): 1172-1175. doi: 10.1016/j.cclet.2017.03.041 shu

Six-step synthesis of Leonurine and toxicity study on zebrafish

Zhao Hui ^a,d,, ,
Hu Xiang-Guo ^b,, ,
Xu Min-Jie ^c ,
Cai Qun-Xing ^d ,
Liu Yu-Jun ^d ,
Su Duo-Meng ^a ,
Chen Shi-Jin ^d ,
Wang Kai ^a ,
Gong Zhu-Nan ^c

a.
Anhui Engineering Technology Research Center for Extraction and Isolation of Active Components, Anhui Academy of Applied Technology, Hefei 230031, China
b.
National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China
c.
School of Life Science, Nanjing Normal University, Nanjing 210023, China
d.
Anhui Academy of Science and Technology, Hefei 230031, China

Corresponding author: Zhao Hui, zh1986@iccas.ac.cn Hu Xiang-Guo, huxiangg@iccas.ac.cn
Received Date: 11 January 2017
Revised Date: 29 March 2017
Accepted Date: 31 March 2017
Available Online: 5 June 2017

Figures(5)

Leonurine (1), an important ingredient in leonurus sibiricus L., can be used for some gynecological disease. We have developed a concise and efficient synthetic route of Leonurine, which can be optimized for mass production. Commercially available compound 6 and 2, 3-dihydrofuran (7) were used as starting materials. And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.
- Leonurine,
- Zebrafish,
- Synthesis,
- Toxcity,
- Oxime
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