Citation: Xue Duo-Qing, Liu Hai-Li, Chen Si-Han, Mollo Ernesto, Gavagnin Margherita, Li Jia, Li Xu-Wen, Guo Yue-Wei. 5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities[J]. Chinese Chemical Letters, ;2017, 28(6): 1190-1193. doi: 10.1016/j.cclet.2017.03.040 shu

5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities

a.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
b.
Institute of Biomolecular Chemistry(ICB) of the National Research Council(CNR), Via Campi Flegrei 34, 80078, Pozzuoli, Napoli, Italy

Corresponding author: Li Xu-Wen, xwli@simm.ac.cn Guo Yue-Wei, ywguo@simm.ac.cn

Received Date: 16 March 2017
Revised Date: 29 March 2017
Accepted Date: 30 March 2017
Available Online: 7 June 2017

Figures(2)

Two new 5-alkylpyrrole-2-carboxaldehyde derivatives, mycalenitrile-15 (1) and mycalenitrile-16 (2), along with five known related ones (3-7), were isolated from the South China Sea sponge Mycale lissochela. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those reported in the literature. In bioassay, compounds 1 and 7 exhibited significant PTP1B (Protein-tyrosine phosphatase 1B, a recognized target for diabetes and obesity) inhibitory activities with IC₅₀ values of 8.6 and 3.1 μmol/L, respectively. A preliminary SAR analysis of the isolated compounds with their PTP1B inhibitory effects was described.
- 5-Alkylpyrrole-2-carboxaldehyde,
- Sponge,
- Mycale lissochela,
- PTP1B inhibitor,
- Marine natural product
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1.
沈阳化工大学材料科学与工程学院沈阳 110142