Citation: Mohebat Razieh, Yazdani-Elah-Abadi Afshin. Caffeine catalyzed green synthesis of novel benzo[a] [1, 3]oxazino[6, 5-c]phenazines via a one-pot multi-component sequential protocol in a basic ionic liquid[J]. Chinese Chemical Letters, ;2017, 28(6): 1340-1344. doi: 10.1016/j.cclet.2017.01.024 shu

Caffeine catalyzed green synthesis of novel benzo[a] [1, 3]oxazino[6, 5-c]phenazines via a one-pot multi-component sequential protocol in a basic ionic liquid

Mohebat Razieh ^a,, ,
Yazdani-Elah-Abadi Afshin ^b

a.
Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Iran
b.
Department of Biology, Science and Art University, Yazd, Iran

Corresponding author: Mohebat Razieh, rozitakalami@gmail.com
Received Date: 25 November 2016
Revised Date: 23 January 2017
Accepted Date: 30 January 2017
Available Online: 2 June 2017

Figures(3)

Caffeine was applied as a green and natural catalyst for the one-pot, four-component sequential condensation between 2-hydroxy-1, 4-naphthoquinone, aromatic 1, 2-diamines, ammonium thiocyanate and acid chlorides in the presence of a basic ionic liquid (1-butyl-3-methylimidazolium hydroxide) to afford the corresponding benzo[a] [1, 3]oxazino[6, 5-c]phenazine derivatives. In this one-pot transformation, five bonds and two new rings are efficiently formed. This protocol has the advantages of operational simplicity, high yields, easy workup, avoidance of hazardous or toxic catalysts and organic solvents and high chemo-and regioselectivities.
- Multi-component reactions (MCRs),
- Green chemistry,
- Ionic liquid,
- Caffeine,
- Oxazine,
- Phenazine
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