Citation: Ma Kai-Qing, Miao Yan-Hong, Gao Xiao-Xia, Chao Jian-Bin, Zhang Xiang, Qin Xue-Mei. Total syntheses of bupleurynol and its analog[J]. Chinese Chemical Letters, ;2017, 28(5): 1035-1038. doi: 10.1016/j.cclet.2016.11.032 shu

Total syntheses of bupleurynol and its analog

a.
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
b.
Department of Chemistry, University of Louisville, Louisville, KY 40208, USA
c.
Scientific Instrument Center, Shanxi University, Taiyuan 030006, China
d.
College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Corresponding author: Ma Kai-Qing, makaiqing@sxu.edu.cn
Received Date: 13 September 2016
Revised Date: 7 November 2016
Accepted Date: 16 November 2016
Available Online: 9 May 2016

Figures(5)

An efficient route to the natural products bupleurynol and its analog (RB-2), isolated from Bupleuri Radix, was established based on versatile intermediate (15). In this synthetic route, Sonogashira and Cadiot-Chodkiewicz coupling as well as Julia-Kocienski olefination are utilized as key steps. The highly efficient synthetic route provides opportunities to explore the biological behavior of bupleurynol and RB-2.
- Polyacetylenes,
- Natural product,
- Bupleurynol,
- Total synthesis,
- Julia-Kocienski olefination
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1.
沈阳化工大学材料科学与工程学院沈阳 110142