Citation: Chen Hai-Jiang, Jiang Yan-Juan, Zhang Yong-Qiang, Jing Qi-Wei, Liu Na, Wang Yan, Zhang Wan-Nian, Sheng Chun-Quan. New triazole derivatives containing substituted 1, 2, 3-triazole side chains: Design, synthesis and antifungal activity[J]. Chinese Chemical Letters, ;2017, 28(4): 913-918. doi: 10.1016/j.cclet.2016.11.027 shu

New triazole derivatives containing substituted 1, 2, 3-triazole side chains: Design, synthesis and antifungal activity

Chen Hai-Jiang ^a,b,1 ,
Jiang Yan-Juan ^a,b,1 ,
Zhang Yong-Qiang ^c,1 ,
Jing Qi-Wei ^b ,
Liu Na ^b ,
Wang Yan ^b ,
Zhang Wan-Nian ^b ,
Sheng Chun-Quan ^a,b,,

a.
School of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, People's Republic of China
b.
School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China
c.
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China

Corresponding author: Sheng Chun-Quan, shengcq@hotmail.com

Received Date: 29 September 2016
Revised Date: 15 November 2016
Accepted Date: 15 November 2016
Available Online: 27 June 2016

Figures(5)

In order to discover new generation of triazole antifungal agents, a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazole-piperdine-heterocycle lead compounds.Several target compounds showed good antifungal activity with a broad spectrum.In particular, compound 7l was highly active against Candida albicans and Candida glabrata.Moreover, compound 7l showed potent in vivo antifungal efficacy in the Caenorhabditis elegans-C.albicans infection model.
- Triazole derivatives,
- Antifungal activities,
- Click reaction,
- Molecular docking,
- CYP51
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