Citation: Liu Meng-Meng, Mei Qiong, Zhang Yi-Xiao, Bai Peng, Guo Xiang-Hai. Palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines with amines[J]. Chinese Chemical Letters, ;2017, 28(3): 583-587. doi: 10.1016/j.cclet.2016.11.019 shu

Palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines with amines

Liu Meng-Meng ^a,b ,
Mei Qiong ^a,b ,
Zhang Yi-Xiao ^a,b ,
Bai Peng ^a,b ,
Guo Xiang-Hai ^a,b,,

a.
Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
b.
Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300350, China

Corresponding author: Guo Xiang-Hai, guoxh@tju.edu.cn
Received Date: 8 October 2016
Revised Date: 25 October 2016
Accepted Date: 31 October 2016
Available Online: 21 March 2016

Figures(5)

A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This synthetic methodology can produce various di-substituted pyrimidines in high yields with good functional group tolerance, and provide a complementary tool for the syntheses of important intermediates of nucleosides and purines with bioactivities.
- Pd-catalyzed,
- C-N coupling reaction,
- Aryl halide,
- Amines,
- Pyrimidines
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