Citation: Ding Gang, Wang Jing, Fei Jiao-Dong, Li Rong-Tao, Jia Hong-Mei, Zhang Tao, Yu Chang-Yuan, Zou Zhong-Mei. Fimbrialtols K-M, highly functionalized ent-kaurane diterpenoids from traditional Chinese plant Flickingeria fimbriata (B1.) Hawkes[J]. Chinese Chemical Letters, ;2017, 28(3): 593-596. doi: 10.1016/j.cclet.2016.10.033 shu

Fimbrialtols K-M, highly functionalized ent-kaurane diterpenoids from traditional Chinese plant Flickingeria fimbriata (B1.) Hawkes

Ding Gang ^a ,
Wang Jing ^a,b ,
Fei Jiao-Dong ^a,b ,
Li Rong-Tao ^c ,
Jia Hong-Mei ^a ,
Zhang Tao ^a ,
Yu Chang-Yuan ^b,, ,
Zou Zhong-Mei ^a,,

a.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
b.
Beijing University of Chemical Technology, Beijing 100029, China
c.
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China

Corresponding author: Yu Chang-Yuan, yucy@mail.buct.edu.cn Zou Zhong-Mei, zmzou@implad.ac.cn
Received Date: 17 August 2016
Revised Date: 13 October 2016
Accepted Date: 19 October 2016
Available Online: 2 March 2016

Figures(2)

Three new ent-kaurane diterpenoids fimbrialtols K-M (3-5) with highly substituted functionalities were isolated from the extract of Flickingeria fimbriata (B1.) Hawkes. The structures of these new compounds were determined by NMR and HR-ESIMS. The relative configurations of these compounds were determined by analysis of NOESY correlations. The absolute configurations of these new compounds were established by CD methods together with considering the biosynthetic pathway. Compounds 3 and 4 contain a cinnamic carboxyl group, whereas compound 5 possesses a benzoic carboxyl group representing the first report in more than known 600 ent-kaurane diterpenoids.
- Flickingeria fimbriata (B1.) Hawkes,
- ent-Kaurane diterpenoids,
- Fimbrialtols,
- NMR,
- CD
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