Citation: Lv Xian-Hai, Ren Zi-Li, Li Dong-Dong, Ruan Ban-Feng, Li Qing-Shan, Chu Ming-Jie, Ai Cheng-Ying, Liu Dao-Hong, Mo Kai, Cao Hai-Qun. Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents[J]. Chinese Chemical Letters, ;2017, 28(2): 377-382. doi: 10.1016/j.cclet.2016.10.029 shu

Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents

a.
School of Plant Protection, Anhui Agricultural University, Hefei 230036, China
b.
School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, China
c.
School of Chemical Engineering, Nanjing Forestry University, Nanjing 210073, China
d.
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China

Corresponding author: Ruan Ban-Feng, ruanbf@huft.edu.cn Cao Hai-Qun, haiquncao@163.com
Received Date: 14 June 2016
Revised Date: 22 August 2016
Accepted Date: 23 September 2016
Available Online: 1 February 2016

Figures(4)

Many pyrazole derivatives were reported to exhibit highly activity towards tobacco mosaic virus (TMV). In this work, an optimized pyrazole Schiff base scaffold was designed and introduced to derive novel potential TMV inhibitors. Thirty-six compounds were synthesized, characterized by elemental analysis, mass spectra and nuclear magnetic resonance (NMR) spectroscopy and evaluated by biological experiments. The bioassay results showed that some of the synthesized compounds exhibited excellent anti-TMV activities. Especially, 5-chloro-3-methyl-1H-pyrazole contained compound 4j showed ningnanmycin comparable inhibitory activity and can be considered as potential anti-TMV candidate agent. With molecular docking, compound 4j insert into nucleotide sequence (GAAGUU) of OriRNA stably which revealed nucleotide could be a target of these compounds.
- Pyrazole,
- Schiff base,
- Anti-TMV,
- Molecule docking
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沈阳化工大学材料科学与工程学院沈阳 110142