Citation: Yin Dong-Hang, Liu Wei, Wang Zhi-Xiang, Huang Xin, Zhang Jing, Huang De-Chun. Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using lipase from Candida sp. 99-125[J]. Chinese Chemical Letters, ;2017, 28(1): 153-158. doi: 10.1016/j.cclet.2016.10.015 shu

Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using lipase from Candida sp. 99-125

a.
Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 210009, China
b.
Department of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210042, China

Corresponding author: Huang De-Chun, cpuhdc@cpu.edu.cn
Received Date: 28 June 2016
Revised Date: 11 July 2016
Accepted Date: 25 July 2016
Available Online: 20 January 2016

Figures(2)

The direct three-component aza-Diels-Alder reaction was conducted with lipase as a catalyst for the first time. Under the optimized conditions, the aza-Diels-Alder reaction catalyzed by lipase from Candida sp. 99-125 provided the products in moderate to excellent yields. Meanwhile, the endo/exo ratio reached up to 88:12.
- Aza-Diels-Alder reaction,
- Lipase,
- Catalysis Candida sp. 99-125,
- Azabicyclo [2.2.2] octan-5-one
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