Citation: Govindaraju Santhosh, Tabassum Sumaiya, Khan Riyaz-ur-Rahaman, Afzal Pasha Mohamed. Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amines[J]. Chinese Chemical Letters, ;2017, 28(2): 437-441. doi: 10.1016/j.cclet.2016.09.013 shu

Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amines

Department of Studies in Chemistry, Central College Campus, Bangalore University, Bengaluru 560001, India

Corresponding author: Afzal Pasha Mohamed, m_af_pasha@ymail.com
Received Date: 12 June 2016
Revised Date: 26 August 2016
Accepted Date: 26 August 2016
Available Online: 21 February 2016

Figures(2)

Meglumine efficiently catalyzes the one-pot, five-component reaction of hydrazine, ethyl acetoacetate, aryl aldehydes, substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amine derivatives. The present approach offers several advantages such as shorter reaction durations, low cost, excellent yields, milder reaction conditions, simple workup procedure and is environment friendly. All the synthesized derivatives are characterized by IR, ¹H NMR, ¹³C NMR, HRMS and CHN analysis.
- One-pot five-component reaction,
- Substituted phenylacetonitriles,
- Meglumine,
- Pyrazolopyridin-6-amines,
- Ethanol
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