Citation: Liu Ji-Mei, Zhang De-Wu, Zhang Min, Chen Ri-Dao, Yan Zheng, Zhao Jian-Yuan, Zhao Jin-Lian, Wang Nan, Dai Jun-Gui. Periconones B-E, new meroterpenoids from endophytic fungus Periconia sp.[J]. Chinese Chemical Letters, ;2017, 28(2): 248-252. doi: 10.1016/j.cclet.2016.07.031 shu

Periconones B-E, new meroterpenoids from endophytic fungus Periconia sp.

Liu Ji-Mei ^a,1 ,
Zhang De-Wu ^a,b,1 ,
Zhang Min ^a ,
Chen Ri-Dao ^a ,
Yan Zheng ^a ,
Zhao Jian-Yuan ^b ,
Zhao Jin-Lian ^a ,
Wang Nan ^a ,
Dai Jun-Gui ^a,,

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peaking Union Medical College, Beijing 100050, China

Corresponding author: Dai Jun-Gui, jgdai@imm.ac.cn

Received Date: 12 June 2016
Revised Date: 14 July 2016
Accepted Date: 24 July 2016
Available Online: 9 February 2016

Figures(4)

Periconones B-E (1-4), four new polyketide-terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism (ECD). Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC₅₀ value of 4.2 μmol/L, and compound 1 displayed anti-HIV activity with an IC₅₀ value of 18.0 μmol/L.
- Meroterpenoids,
- Periconia,
- Endophytic fungus,
- Annona muricata,
- Periconone
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