Citation: Lei-Lei Rui, Hong-Liang Cao, Yu-Dong Xue, Li-Chao Liu, Lei Xu, Yun Gao, Wei-An Zhang. Functional organic nanoparticles for photodynamic therapy[J]. Chinese Chemical Letters, ;2016, 27(8): 1412-1420. doi: 10.1016/j.cclet.2016.07.011 shu

Functional organic nanoparticles for photodynamic therapy

Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Hong-Liang Cao, caohl@ecust.edu.cn Yun Gao, zhqpan@ecust.edu.cn Wei-An Zhang, wazhang@ecust.edu.cn
Received Date: 3 May 2016
Revised Date: 5 July 2016
Accepted Date: 6 July 2016
Available Online: 18 August 2016

Figures(7)

In recent years, cancer has been one of the leading causes of death in the world. Much effort has been devoted to developing cancer treatments. Photodynamic therapy (PDT) is a noninvasive therapeutic modality by combining the light of a specific wavelength, a photosensitizer (PS) and oxygen, which has been widely applied for the treatment of cancers. However, the application of PDT in clinic is greatly limited due to lack of tumor selectivity and often causing skin photosensitivity. The use of organic nanoparticles (NPs) as an advanced technology in the field of PDT shows a great promise to overcome these shortcomings. Therefore, in this review, we summarize several functional organic NPs as PS carriers that have been developed to enhance the efficacy of PDT against cancers.
- Photosensitizers,
- Photodynamic therapy,
- Organic nanoparticles,
- Singlet oxygen,
- Cancer treatment
1. [1]
  M. Ferrari. Cancer nanotechnology: opportunities and challenges[J]. Nat. Rev. Cancer, 2005,5:161-171. doi: 10.1038/nrc1566
2. [2]
  T.J. Dougherty, G.B. Grindey, R. Fiel, K.R. Weishaupt, D.G. Boyle. photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light[J]. J. Natl. Cancer Inst., 1975,55:115-121.
3. [3]
  W.M. Sharman, C.M. Allen, J.E. van Lier. Role of activated oxygen species in photodynamic therapy, in: Methods in Enzymology[J]. Academic Press, New York, 2000,pp.:367-400.
4. [4]
  D.E.J.G.J. Dolmans, D. Fukumura, R.K. Jain. Photodynamic therapy for cancer[J]. Nat. Rev. Cancer, 2003,3:380-387. doi: 10.1038/nrc1071
5. [5]
  P. Mroz, A. Yaroslavsky, G.B. Kharkwal, M.R. Hamblin. Cell death pathways in photodynamic therapy of cancer[J]. Cancers, 2011,3:2516-2539. doi: 10.3390/cancers3022516
6. [6]
  P. Baluk, H. Hashizume, D.M. McDonald. Cellular abnormalities of blood vessels as targets in cancer[J]. Curr. Opin. Genet. Dev., 2005,15:102-111. doi: 10.1016/j.gde.2004.12.005
7. [7]
  C. Abels. Targeting of the vascular system of solid tumours by photodynamic therapy (PDT)[J]. Photochem. Photobiol. Sci., 2004,3:765-771. doi: 10.1039/b314241h
8. [8]
  R.R. Allison, K. Moghissi. Photodynamic therapy (PDT): PDT mechanisms[J]. Clin. Endosc., 2013,46:24-29. doi: 10.5946/ce.2013.46.1.24
9. [9]
  M. Niedre, M.S. Patterson, B.C. Wilson. Direct near-infrared luminescence detection of singlet oxygen generated by photodynamic therapy in cells in vitro and tissues in vivo[J]. Photochem. Photobiol., 2002,75:382-391. doi: 10.1562/0031-8655(2002)0750382DNILDO2.0.CO2
10. [10]
  J. Moan, K. Berg. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen[J]. Photochem. Photobiol., 1991,53:549-553. doi: 10.1111/php.1991.53.issue-4
11. [11]
  B. Green, A.R.M. Cobb, C. Hopper. Photodynamic therapy in the management of lesions of the head and neck[J]. Br. J. Oral Maxillofac. Surg., 2013,51:283-287. doi: 10.1016/j.bjoms.2012.11.011
12. [12]
  R. Allison, K. Moghissi, G. Downie, K. Dixon. Photodynamic therapy (PDT) for lung cancer[J]. Photodiagnosis Photodyn. Ther., 2011,8:231-239. doi: 10.1016/j.pdpdt.2011.03.342
13. [13]
  M.B. Ericson, A.M. Wennberg, O. Larkö. Review of photodynamic therapy in actinic keratosis and basal cell carcinoma[J]. Ther. Clin. Risk Manag., 2008,4:1-9.
14. [14]
  C.M.B. Carvalho, J.P.C. Tomé, M.A.F. Faustino. Antimicrobial photodynamic activity of porphyrin derivatives: potential application on medical and water disinfection[J]. J. Porphyrins Phthalocyanines, 2009,13:574-577. doi: 10.1142/S1088424609000528
15. [15]
  S.S. Lucky, K.C. Soo, Y. Zhang. Nanoparticles in photodynamic therapy[J]. Chem. Rev., 2015,115:1990-2042. doi: 10.1021/cr5004198
16. [16]
  K.K. Ng, G. Zheng. Molecular interactions in organic nanoparticles for phototheranostic applications[J]. Chem. Rev., 2015,115:11012-11042. doi: 10.1021/acs.chemrev.5b00140
17. [17]
  W.M. Sharman, J.E. van Lier, C.M. Allen. Targeted photodynamic therapy via receptor mediated delivery systems[J]. Adv. Drug Deliv. Rev., 2004,56:53-76. doi: 10.1016/j.addr.2003.08.015
18. [18]
  D. Kozlowska, P. Foran, P. MacMahon. Molecular and magnetic resonance imaging: the value of immunoliposomes[J]. Adv. Drug Deliv. Rev., 2009,61:1402-1411. doi: 10.1016/j.addr.2009.09.003
19. [19]
  M. Ethirajan, Y.H. Chen, P. Joshi, R.K. Pandey. The role of porphyrin chemistry in tumor imaging and photodynamic therapy[J]. Chem. Soc. Rev., 2011,40:340-362. doi: 10.1039/B915149B
20. [20]
  T.A. Debele, S. Peng, H.C. Tsai. Drug carrier for photodynamic cancer therapy[J]. Int. J. Mol. Sci., 2015,16:22094-22136. doi: 10.3390/ijms160922094
21. [21]
  A.B. Ormond, H.S. Freeman. Dye sensitizers for photodynamic therapy[J]. Materials, 2013,6:817-840. doi: 10.3390/ma6030817
22. [22]
  S.S. Stylli, A.H. Kaye, L. MacGregor, M. Howes, P. Rajendra. Photodynamic therapy of high grade glioma-long term survival[J]. J. Clin. Neurosci., 2005,12:389-398. doi: 10.1016/j.jocn.2005.01.006
23. [23]
  C. Staneloudi, K.A. Smith, R. Hudson. Development and characterization of novel photosensitizer: scFv conjugates for use in photodynamic therapy ofcancer[J]. Immunology, 2007,120:512-517. doi: 10.1111/j.1365-2567.2006.02522.x
24. [24]
  R.R. Allison. Photodynamic therapy: oncologic horizons[J]. Future Oncol., 2014,10:123-124. doi: 10.2217/fon.13.176
25. [25]
  Z. Huang, H.P. Xu, A.D. Meyers. Photodynamic therapy for treatment of solid tumors-potential and technical challenges[J]. Technol. Cancer Res. Treat., 2008,7:309-320. doi: 10.1177/153303460800700405
26. [26]
  A. Prokop, J.M. Davidson. Nanovehicular intracellular delivery systems[J]. J. Pharm. Sci., 2008,97:3518-3590. doi: 10.1002/jps.21270
27. [27]
  C. Luo, J. Sun, B.J. Sun, Z.G. He. Prodrug-based nanoparticulate drug delivery strategies for cancer therapy[J]. Trends Pharm. Sci., 2014,35:556-566. doi: 10.1016/j.tips.2014.09.008
28. [28]
  E. Paszko, C. Ehrhardt, M.O. Senge, D.P. Kelleher, J.V. Reynolds. Nanodrug applications in photodynamic therapy[J]. Photodiagn. Photodyn. Ther., 2011,8:14-29. doi: 10.1016/j.pdpdt.2010.12.001
29. [29]
  Y.N. Konan, R. Gurny, E. Allémann. State of the art in the delivery of photosensitizers for photodynamic therapy[J]. J. Photochem. Photobiol. B: Biol., 2002,66:89-106. doi: 10.1016/S1011-1344(01)00267-6
30. [30]
  R.R. Sawant, V.P. Torchilin. Liposomes as ‘smart’ pharmaceutical nanocarriers[J]. Soft Matter, 2010,6:4026-4044. doi: 10.1039/b923535n
31. [31]
  J.F. Lovell, C.S. Jin, E. Huynh. Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents[J]. Nat. Mater., 2011,10:324-332. doi: 10.1038/nmat2986
32. [32]
  E. Huynh, G. Zheng. Porphysome nanotechnology: a paradigm shift in lipid-based supramolecular structures[J]. Nano Today, 2014,9:212-222. doi: 10.1016/j.nantod.2014.04.012
33. [33]
  A.S.L. Derycke, P.A.M. de Witte. Liposomes for photodynamic therapy[J]. Adv. Drug Deliv. Rev., 2004,56:17-30. doi: 10.1016/j.addr.2003.07.014
34. [34]
  D.D. Lasic, F.J. Martin, A. Gabizon, S.K. Huang, D. Papahadjopoulos. Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times[J]. Biochim. Biophys. Acta, 1991,1070:187-192. doi: 10.1016/0005-2736(91)90162-2
35. [35]
  Y. Sadzuka, F. Iwasaki, I. Sugiyama. Phototoxicity of coproporphyrin as a novel photodynamic therapy was enhanced by liposomalization[J]. Toxicol. Lett., 2008,182:110-114. doi: 10.1016/j.toxlet.2008.09.002
36. [36]
  R. Rahmanzadeh, P. Rai, J.P. Celli. Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer[J]. Cancer Res., 2010,70:9234-9242. doi: 10.1158/0008-5472.CAN-10-1190
37. [37]
  N. Oku, T. Ishii. Chapter 16: Antiangiogenic photodynamic therapy with targeted liposomes, in: Methods in Enzymology[J]. Academic Press, New York, 2009,pp.:313-330.
38. [38]
  C.S. Jin, L.Y. Cui, F. Wang, J. Chen, G. Zheng. Targeting-triggered porphysome nanostructure disruption for activatable photodynamic therapy[J]. Adv. Healthc. Mater., 2014,3:1240-1249. doi: 10.1002/adhm.v3.8
39. [39]
  C.S. Jin, G. Zheng. Liposomal nanostructures for photosensitizer delivery[J]. Lasers Surg. Med., 2011,43:734-748. doi: 10.1002/lsm.v43.7
40. [40]
  P. Skupin-Mrugalska, J. Piskorz, T. Goslinski. Current status of liposomal porphyrinoid photosensitizers[J]. Drug Discov. Today, 2013,18:776-784. doi: 10.1016/j.drudis.2013.04.003
41. [41]
  A. Yavlovich, B. Smith, K. Gupta, R. Blumenthal, A. Puri. Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications[J]. Mol. Membr. Biol., 2010,27:364-381. doi: 10.3109/09687688.2010.507788
42. [42]
  S. Simões, J.N. Moreira, C. Fonseca, N. Düzgüneş, M.C. Pedroso de Lima. On the formulation of pH-sensitive liposomes with long circulation times[J]. Adv. Drug Deliv. Rev., 2004,56:947-965. doi: 10.1016/j.addr.2003.10.038
43. [43]
  B. Spring, Z.M. Mai, P. Rai, S. Chang, T. Hasan, Theranostic nanocells for simultaneous imaging and photodynamic therapy of pancreatic cancer, in: Proceedings of SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, SPIE, San Francisco, CA, 2010, pp. 755104-755111.
44. [44]
  X.L. Liang, X.D. Li, X.L. Yue, Z.F. Dai. Conjugation of porphyrin to nanohybrid cerasomes for photodynamic diagnosis and therapy of cancer[J]. Angew. Chem. Int. Ed., 2011,50:11622-11627. doi: 10.1002/anie.201103557
45. [45]
  O. Salata. Applications of nanoparticles in biology and medicine[J]. J. Nanobiotechnol., 2004,23. doi: 10.1186/1477-3155-2-3
46. [46]
  Y.M. Zhou, X.L. Liang, Z.F. Dai. Porphyrin-loaded nanoparticles for cancer theranostics[J]. Nanoscale, 2016,8:12394-12405. doi: 10.1039/C5NR07849K
47. [47]
  S.Y. Wang, W.Z. Fan, G. Kim. Novel methods to incorporate photosensitizers into nanocarriers for cancer treatment by photodynamic therapy[J]. Lasers Surg. Med., 2011,43:686-695. doi: 10.1002/lsm.v43.7
48. [48]
  A.O. Elzoghby, W.M. Samy, N.A. Elgindy. Albumin-based nanoparticles as potential controlled release drug delivery systems[J]. J. Control. Release, 2012,157:168-182. doi: 10.1016/j.jconrel.2011.07.031
49. [49]
  K.Y. Choi, H. Chung, K.H. Min. Self-assembled hyaluronic acid nanoparticles for active tumor targeting[J]. Biomaterials, 2010,31:106-114. doi: 10.1016/j.biomaterials.2009.09.030
50. [50]
  S.M. Abdelghany, D. Schmid, J. Deacon. Enhanced antitumor activity of the photosensitizer meso-tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles[J]. Biomacromolecules, 2013,14:302-310. doi: 10.1021/bm301858a
51. [51]
  J. Panyam, V. Labhasetwar. Biodegradable nanoparticles for drug and gene delivery to cells and tissue[J]. Adv. Drug Deliv. Rev., 2003,55:329-347. doi: 10.1016/S0169-409X(02)00228-4
52. [52]
  D. Bechet, P. Couleaud, C. Frochot. Nanoparticles as vehicles for delivery of photodynamic therapy agents[J]. Trends Biotechnol., 2008,26:612-621. doi: 10.1016/j.tibtech.2008.07.007
53. [53]
  D.K. Chatterjee, L.S. Fong, Y. Zhang. Nanoparticles in photodynamic therapy: an emerging paradigm[J]. Adv. Drug Deliv. Rev., 2008,60:1627-1637. doi: 10.1016/j.addr.2008.08.003
54. [54]
  J.R. McCarthy, J.M. Perez, C. Brückner, R. Weissleder. Polymeric nanoparticle preparation that eradicates tumors[J]. Nano Lett., 2005,5:2552-2556. doi: 10.1021/nl0519229
55. [55]
  A. Beletsi, Z. Panagi, K. Avgoustakis. Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers[J]. Int. J. Pharm., 2005,298:233-241. doi: 10.1016/j.ijpharm.2005.03.024
56. [56]
  C. Conte, F. Ungaro, G. Maglio. Biodegradable core-shell nanoassemblies for the delivery of docetaxel and Zn(II)-phthalocyanine inspired by combination therapy for cancer[J]. J. Control. Release, 2013,167:40-52. doi: 10.1016/j.jconrel.2012.12.026
57. [57]
  S.Y. Wang, G. Kim, Y.E.K. Lee. Multifunctional biodegradable polyacrylamide nanocarriers for cancer theranostics-a "see and treat" strategy[J]. ACS Nano, 2012,6:6843-6851. doi: 10.1021/nn301633m
58. [58]
  H. Wu, H.H. Wang, H. Liao. Multifunctional nanostructures for tumortargeted molecular imaging and photodynamic therapy[J]. Adv. Healthc. Mater., 2016,5:311-318. doi: 10.1002/adhm.v5.3
59. [59]
  H. Gong, Z.L. Dong, Y.M. Liu. Engineering of multifunctional nano-micelles for combined photothermal and photodynamic therapy under the guidance of multimodal imaging[J]. Adv. Funct. Mater., 2014,24:6492-6502. doi: 10.1002/adfm.v24.41
60. [60]
  O. Taratula, B.S. Doddapaneni, C. Schumann. Naphthalocyanine-based biodegradable polymeric nanoparticles for image-guided combinatorial phototherapy[J]. Chem. Mater., 2015,27:6155-6165. doi: 10.1021/acs.chemmater.5b03128
61. [61]
  W.L. Kim, H. Cho, L. Li, H.C. Kang, K.M. Huh. Biarmed poly(ethylene glycol)-(pheophorbide a)₂ conjugate as a bioactivatable delivery carrier for photodynamic therapy[J]. Biomacromolecules, 2014,15:2224-2234. doi: 10.1021/bm5003619
62. [62]
  H.C. Chen, J.W. Tian, W.J. He, Z.J. Guo. H₂O₂-activatable and O₂-evolving nanoparticles for highly efficient and selective photodynamic therapy against hypoxic tumor cells[J]. J. Am. Chem. Soc., 2015,137:1539-1547. doi: 10.1021/ja511420n
63. [63]
  D.S. Ling, W. Park, S.J. Park. Multifunctional tumor pH-sensitive selfassembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors[J]. J. Am. Chem. Soc., 2014,136:5647-5655. doi: 10.1021/ja4108287
64. [64]
  T.T. Wang, D.G. Wang, H.J. Yu. Intracellularly acid-switchable multifunctional micelles for combinational photo/chemotherapy of the drug-resistant tumor[J]. ACS Nano, 2016,10:3496-3508. doi: 10.1021/acsnano.5b07706
65. [65]
  S.I. Shoda, H. Uyama, J.I. Kadokawa, S. Kimura, S. Kobayashi. Enzymes as green catalystsforprecisionmacromolecularsynthesis[J]. Chem.Rev., 2016,116:2307-2413. doi: 10.1021/acs.chemrev.5b00472
66. [66]
  Y. Choi, R. Weissleder, C.H. Tung. Selective antitumor effect of novel proteasemediated photodynamic agent[J]. Cancer Res., 2006,66:7225-7229. doi: 10.1158/0008-5472.CAN-06-0448
67. [67]
  K. Han, S.B. Wang, Q. Lei, J.Y. Zhu, X.Z. Zhang. Ratiometric biosensor for aggregation-induced emission-guided precise photodynamic therapy[J]. ACS Nano, 2015,9:10268-10277. doi: 10.1021/acsnano.5b04243
68. [68]
  S.Y. Li, H. Cheng, W.X. Qiu. Protease-activable cell-penetrating peptideprotoporphyrin conjugate for targeted photodynamic therapy in vivo[J]. ACS Appl. Mater. Interfaces, 2015,7:28319-28329. doi: 10.1021/acsami.5b08637
69. [69]
  Y.Y. Yuan, C.J. Zhang, B. Liu. A photoactivatable AIE polymer for light-controlled gene delivery: concurrent endo/lysosomal escape and DNA unpacking[J]. Angew. Chem. Int. Ed., 2015,54:11419-11423. doi: 10.1002/anie.201503640
70. [70]
  H.B. Chen, L. Xiao, Y. Anraku. Polyion complex vesicles for photoinduced intracellular delivery of amphiphilic photosensitizer[J]. J. Am. Chem. Soc., 2014,136:157-163. doi: 10.1021/ja406992w
71. [71]
  A.M. Bugaj. Targeted photodynamic therapy- a promising strategy of tumor treatment[J]. Photochem. Photobiol. Sci., 2011,10:1097-1109. doi: 10.1039/c0pp00147c
72. [72]
  L.S. Nair, C.T. Laurencin. Biodegradable polymers as biomaterials[J]. Prog. Polym. Sci., 2007,32:762-798. doi: 10.1016/j.progpolymsci.2007.05.017
73. [73]
  W.J. Gradishar. Albumin-bound paclitaxel: a next-generation taxane[J]. Expert Opin. Pharmacother., 2006,7:1041-1053. doi: 10.1517/14656566.7.8.1041
74. [74]
  M. Wacker, K. Chen, A. Preuss. Photosensitizer loaded HSA nanoparticles. I: Preparation and photophysical properties[J]. Int. J. Pharm., 2010,393:254-263. doi: 10.1016/j.ijpharm.2010.04.022
75. [75]
  Z.H. Sheng, D.H. Hu, M.B. Zheng. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy[J]. ACS Nano, 2014,8:12310-12322. doi: 10.1021/nn5062386
76. [76]
  Q. Chen, X.D. Liu, J.W. Chen. A self-assembled albumin-based nanoprobe for in vivo ratiometric photoacoustic pH imaging[J]. Adv. Mater., 2015,27:6820-6827. doi: 10.1002/adma.201503194
77. [77]
  T.C. Laurent, J.R. Fraser. Hyaluronan[J]. FASEB J., 1992,6:2397-2404.
78. [78]
  J. Necas, L. Bartosikova, P. Brauner, J. Kolar. Hyaluronic acid (hyaluronan): a review[J]. Vet. Med., 2008,53:397-411.
79. [79]
  H.Y. Yoon, H. Koo, K.Y. Choi. Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy[J]. Biomaterials, 2012,33:3980-3989. doi: 10.1016/j.biomaterials.2012.02.016
80. [80]
  J. Han, W. Park, S.J. Park, K. Na. Photosensitizer-conjugated hyaluronic acidshielded polydopamine nanoparticles for targeted photomediated tumor therapy[J]. ACS Appl. Mater. Interfaces, 2016,8:7739-7747. doi: 10.1021/acsami.6b01664
81. [81]
  R. Hejazi, M. Amiji. Chitosan-based gastrointestinal delivery systems[J]. J. Control. Release, 2003,89:151-165. doi: 10.1016/S0168-3659(03)00126-3
82. [82]
  J.H. Kim, Y.S. Kim, K. Park. Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy[J]. Biomaterials, 2008,29:1920-1930. doi: 10.1016/j.biomaterials.2007.12.038
83. [83]
  I.H. Oh, H.S. Min, L. Li. Cancer cell-specific photoactivity of pheophorbide aglycol chitosan nanoparticles for photodynamic therapy in tumor-bearing mice[J]. Biomaterials, 2013,34:6454-6463. doi: 10.1016/j.biomaterials.2013.05.017
84. [84]
  Z.X. Liao, Y.C. Li, H.M. Lu, H.W. Sung. A genetically-encoded KillerRed protein as an intrinsically generated photosensitizer for photodynamic therapy[J]. Biomaterials, 2014,35:500-508. doi: 10.1016/j.biomaterials.2013.09.075
1. [1]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
2. [2]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
3. [3]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
4. [4]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
5. [5]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
6. [6]
  Qihang Wu , Hui Wen , Wenhai Lin , Tingting Sun , Zhigang Xie . Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment. Chinese Chemical Letters, 2024, 35(12): 109692-. doi: 10.1016/j.cclet.2024.109692
7. [7]
  Shenghui Tu , Anru Liu , Hongxiang Zhang , Lu Sun , Minghui Luo , Shan Huang , Ting Huang , Honggen Peng . Oxygen vacancy regulating transition mode of MIL-125 to facilitate singlet oxygen generation for photocatalytic degradation of antibiotics. Chinese Chemical Letters, 2024, 35(12): 109761-. doi: 10.1016/j.cclet.2024.109761
8. [8]
  Rongxin Zhu , Shengsheng Yu , Xuanzong Yang , Ruyu Zhu , Hui Liu , Kaikai Niu , Lingbao Xing . Construction of pyrene-based hydrogen-bonded organic frameworks as photocatalysts for photooxidation of styrene in water. Chinese Chemical Letters, 2024, 35(10): 109539-. doi: 10.1016/j.cclet.2024.109539
9. [9]
  Yan Zhu , Jia Liu , Meiheng Lv , Tingting Wang , Dongxiang Zhang , Rong Shang , Xin-Dong Jiang , Jianjun Du , Guiling Wang . Heavy-atom-free orthogonal configurative dye 1,7-di-anthra-aza-BODIPY for singlet oxygen generation. Chinese Chemical Letters, 2024, 35(10): 109446-. doi: 10.1016/j.cclet.2023.109446
10. [10]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
11. [11]
  Chi Zhang , Ning Ding , Yuwei Pan , Lichun Fu , Ying Zhang . The degradation pathways of contaminants by reactive oxygen species generated in the Fenton/Fenton-like systems. Chinese Chemical Letters, 2024, 35(10): 109579-. doi: 10.1016/j.cclet.2024.109579
12. [12]
  Di An , Mingdong She , Ziyang Zhang , Ting Zhang , Miaomiao Xu , Jinjun Shao , Qian Shen , Xuna Tang . Light-responsive nanomaterials for biofilm removal in root canal treatment. Chinese Chemical Letters, 2025, 36(2): 109841-. doi: 10.1016/j.cclet.2024.109841
13. [13]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
14. [14]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
15. [15]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
16. [16]
  Wenkai Liu , Yanxian Hou , Weijian Liu , Ran Wang , Shan He , Xiang Xia , Chengyuan Lv , Hua Gu , Qichao Yao , Qingze Pan , Zehou Su , Danhong Zhou , Wen Sun , Jiangli Fan , Xiaojun Peng . Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process. Chinese Chemical Letters, 2024, 35(12): 109631-. doi: 10.1016/j.cclet.2024.109631
17. [17]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
18. [18]
  Zhongyu Wang , Lijun Wang , Huaixin Zhao . DNA-based nanosystems to generate reactive oxygen species for nanomedicine. Chinese Chemical Letters, 2024, 35(11): 109637-. doi: 10.1016/j.cclet.2024.109637
19. [19]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
20. [20]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(3894)
HTML views(78)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142