Citation: Huo Jing-Qian, Ma Liu-Yong, Zhang Zhe, Fan Zhi-Jin, Zhang Jin-Lin, Tetyana V. Beryozkina, Vasiliy A. Bakulev. Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives[J]. Chinese Chemical Letters, ;2016, 27(9): 1547-1550. doi: 10.1016/j.cclet.2016.06.019 shu

Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives

a.
College of Plant Protection, Agricultural University of Hebei, Baoding 071001, China
b.
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
c.
Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin 300071, China
d.
The Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia

Received Date: 23 May 2016
Revised Date: 2 June 2016
Accepted Date: 7 June 2016
Available Online: 17 September 2016

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A series of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives were designed and synthesized. Their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis (L) Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii.
- Amides derivative,
- Pyrazole,
- Furan,
- Synthesis,
- Herbicidal activity,
- Fungicidal activity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142