Citation: Mubarak H. Shaikh, Dnyaneshwar D. Subhedar, Firoz A. Kalam Khan, Jaiprakash N. Sangshetti, Bapurao B. Shingate. 1,2,3-Triazole incorporated coumarin derivatives as potential antifungal and antioxidant agents[J]. Chinese Chemical Letters, ;2016, 27(02): 295-301. doi: 10.1016/j.cclet.2015.11.003 shu

1,2,3-Triazole incorporated coumarin derivatives as potential antifungal and antioxidant agents

a.
a. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India;
b.
b. Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad 431001, India

Corresponding author: Bapurao B. Shingate,
Received Date: 10 March 2015
Available Online: 7 July 2015

A series of novel ethyl-7-((1-(benzyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-oxo-2H-chromene-3-carboxylates 8a-h as potential antifungal agents were synthesized via click chemistry. The antifungal activity was evaluated against five human pathogenic fungal strains, such as Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger and Cryptococcus neoformans. Compound 8c, 8d, 8e and 8h were found to be equipotent against C. albicans when compared with miconazole and compound 8f was found to be two-fold more active compared with miconazole and equipotent to fluconazole against C. albicans. The coumarin-based triazole derivatives were also evaluated for antioxidant activity and compound 8a was found to be potent antioxidant when compared with standard drug. Furthermore, molecular docking study of the newly synthesized compounds was performed and results showed good binding mode in the active site of fungal C. albicans enzyme P450 cytochrome lanosterol 14α-emethylase. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential to build up as good oral drug candidates.
- ADME prediction,
- Antifungal,
- Antioxidant,
- Docking study,
- 1,2,3-Triazole
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